KATP channels and cardioprotection [PDF]
Arhiv za farmacijuThis review discusses ATP-sensitive potassium (KATP) channels, which connect intracellular energy metabolism to cellular electrical activity and play crucial roles in various physiological processes, particularly in the pancreas and cardiovascular system.
Taskin Eylem +5 more
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The unusual stoichiometry of ADP activation of the KATP channel [PDF]
Frontiers in Physiology, 2014 KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Eric eHosy, Michel eVivaudou
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Membrane trafficking of ATP-sensitive potassium channels [PDF]
, 2005 ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
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Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine. [PDF]
Pharmaceuticals (Basel), 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Dyhring T +3 more
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Frontiers in Pharmacology, 2022 ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate ...
Zhicheng Wang +4 more
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Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. [PDF]
PLoS ONE, 2016 The search for new approaches to treatment and prevention of heart failure is a major challenge in medicine. The adenosine triphosphate-sensitive potassium (KATP) channel has been long associated with the ability to preserve myocardial function and ...
Zhan Gao +8 more
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Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]
, 1999 Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
Perciaccante, J. V. +3 more
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Regulation of KATP channel activity [PDF]
, 2021 ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response
Usher, Samuel
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Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons [PDF]
, 2016 Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of
McCrimmon, Rory J.; id_orcid +18 more
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Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]
, 2005 BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M +27 more
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