Results 11 to 20 of about 14,110 (214)
Regulation of KATP channel activity
, 2021 ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response to the intracellular ATP/ADP ratio.
Usher, Samuel
openaire +3 more sources
Molecular determinants of KATP channel inhibition by ATP [PDF]
EMBO Journal, 1998 ATP-sensitive K+ (KATP) channels are both inhibited and activated by intracellular nucleotides, such as ATP and ADP. The inhibitory effects of nucleotides are mediated via the pore-forming subunit, Kir6.2, whereas the potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR.
Stephen J Tucker +2 more
exaly +4 more sources
The unusual stoichiometry of ADP activation of the KATP channel
Frontiers in Physiology, 2014 KATP channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR.
Eric eHosy, Michel eVivaudou
doaj +2 more sources
Regulation of mitochondrial KATP channel by redox agents
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999 The ATP-dependent K+ channel (KATP) was purified from the inner mitochondrial membrane and reconstituted into lipid bilayer membranes. KATP activity was inhibited by high concentrations of ATP and ADP, but activated by low concentrations (up to 200 microM) of ADP.
Grigoriev, S.M. +3 more
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Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle
Scientific Reports, 2021 Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, the most severe end of neonatal diabetes mellitus, is caused by mutation in the ATP-sensitive potassium (KATP) channel.
Shoichiro Horita +8 more
doaj +2 more sources
Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine. [PDF]
Pharmaceuticals (Basel), 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Dyhring T +3 more
europepmc +2 more sources
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Channels, 2022 ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection.
Bo Yang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate ...
Zhicheng Wang +4 more
doaj +1 more source
Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. [PDF]
PLoS ONE, 2016 The search for new approaches to treatment and prevention of heart failure is a major challenge in medicine. The adenosine triphosphate-sensitive potassium (KATP) channel has been long associated with the ability to preserve myocardial function and ...
Zhan Gao +8 more
doaj +1 more source
Role of KATP channels in sepsis [PDF]
Cardiovascular Research, 2006 Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure.
James F, Buckley +2 more
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