Results 21 to 30 of about 14,110 (214)

Intellectual disability in KATP channel neonatal diabetes [PDF]

Yearbook of Paediatric Endocrinology, 2020
OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized.
Pernille Svalastoga, Åsta Sulen, Jarle R. Fehn, Stein M. Aukland, Henrik Irgens, Eivind Sirnes, Silje K.E. Fevang, Eivind Valen, Irene B. Elgen, Pål R. Njølstad   +9 more
openaire   +2 more sources

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons [PDF]

, 2016
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of
McCrimmon, Rory J.; id_orcid, Ashford, ML, Haythorne, Elizabeth, Hamilton, D. Lee, Haythorne, E, McCrimmon, Rory J., McCrimmon, Rory J, Hamilton, DL, Ashford, Michael L J, Hathorne , Elizabeth, Beall, Craig, Findlay, John A, Hamilton, David Lee, Findlay, John A., Findlay, JA, Ashford, Michael L. J.; id_orcid, Beall, C, McCrimmon, RJ, Ashford, Michael L.J.   +18 more
core   +2 more sources

Endocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells

Cell Reports, 2018
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depends on the inhibition of KATP channel activity in HG.
Young-Eun Han, Jung Nyeo Chun, Min Jeong Kwon, Young-Sun Ji, Myong-Ho Jeong, Hye-Hyun Kim, Sun-Hyun Park, Jong Cheol Rah, Jong-Sun Kang, Suk-Ho Lee, Won-Kyung Ho   +10 more
doaj   +1 more source

Octameric Stoichiometry of the KATP Channel Complex [PDF]

The Journal of General Physiology, 1997
ATP-sensitive potassium (KATP) channels link cellular metabolism to electrical activity in nerve, muscle, and endocrine tissues. They are formed as a functional complex of two unrelated subunits—a member of the Kir inward rectifier potassium channel family, and a sulfonylurea receptor (SUR), a member of the ATP-binding cassette transporter family ...
S, Shyng, C G, Nichols
openaire   +2 more sources

Memantine has no effect on KATP channels in pancreatic β cells

BMC Research Notes, 2018
Objective Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death.
Ryota Imai, Shingen Misaka, Shoichiro Horita, Shoko Yokota, Rie O’hashi, Yuko Maejima, Kenju Shimomura   +6 more
doaj   +1 more source

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Cell Reports, 2023
Summary: The ATP-sensitive K+ (KATP) channel is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of KATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice,
Thuong Ho, Evgeniy Potapenko, Dawn B. Davis, Matthew J. Merrins   +3 more
doaj   +1 more source

A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]

, 2001
Low concentrations of certain K_ATP channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J., Ian MacKenzie, Basil J Northover, Antony J Workman, MacKenzie, I., Workman, A.J.   +5 more
core   +1 more source

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

Frontiers in Cellular Neuroscience, 2014
Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak, Maria S. Lemak, Oksana eVoloshanenko, Andreas eDraguhn, Andreas eDraguhn, Alexei V. Egorov, Alexei V. Egorov   +6 more
doaj   +1 more source

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

iScience, 2022
Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce ...
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya   +18 more
doaj   +1 more source

Expression of ATP-sensitive potassium channels in human pregnant myometrium

Reproductive Biology and Endocrinology, 2011
Background Potassium channels play critical roles in the regulation of cell membrane potential, which is central to the excitability of myometrium. The ATP-sensitive potassium (KATP) channel is one of the most abundant potassium channels in myometrium ...
Hui Ning, Hu Rong, Zhang Lanmei, Gao Lu, You Xingji, Xu Chen, Olson David M, Ni Xin   +7 more
doaj   +1 more source