Results 21 to 30 of about 1,219,583 (164)

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source

Endocytosis of KATP Channels Drives Glucose-Stimulated Excitation of Pancreatic β Cells

Cell Reports, 2018
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depends on the inhibition of KATP channel activity in HG.
Young-Eun Han, Jung Nyeo Chun, Min Jeong Kwon, Young-Sun Ji, Myong-Ho Jeong, Hye-Hyun Kim, Sun-Hyun Park, Jong Cheol Rah, Jong-Sun Kang, Suk-Ho Lee, Won-Kyung Ho   +10 more
doaj   +1 more source

Memantine has no effect on KATP channels in pancreatic β cells

BMC Research Notes, 2018
Objective Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death.
Ryota Imai, Shingen Misaka, Shoichiro Horita, Shoko Yokota, Rie O’hashi, Yuko Maejima, Kenju Shimomura   +6 more
doaj   +1 more source

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Cell Reports, 2023
Summary: The ATP-sensitive K+ (KATP) channel is a key regulator of hormone secretion from pancreatic islet endocrine cells. Using direct measurements of KATP channel activity in pancreatic β cells and the lesser-studied α cells, from both humans and mice,
Thuong Ho, Evgeniy Potapenko, Dawn B. Davis, Matthew J. Merrins   +3 more
doaj   +1 more source

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

Frontiers in Cellular Neuroscience, 2014
Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak, Maria S. Lemak, Oksana eVoloshanenko, Andreas eDraguhn, Andreas eDraguhn, Alexei V. Egorov, Alexei V. Egorov   +6 more
doaj   +1 more source

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

iScience, 2022
Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce ...
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya   +18 more
doaj   +1 more source

Expression of ATP-sensitive potassium channels in human pregnant myometrium

Reproductive Biology and Endocrinology, 2011
Background Potassium channels play critical roles in the regulation of cell membrane potential, which is central to the excitability of myometrium. The ATP-sensitive potassium (KATP) channel is one of the most abundant potassium channels in myometrium ...
Hui Ning, Hu Rong, Zhang Lanmei, Gao Lu, You Xingji, Xu Chen, Olson David M, Ni Xin   +7 more
doaj   +1 more source

A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]

, 2001
Low concentrations of certain K_ATP channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J., Ian MacKenzie, Basil J Northover, Antony J Workman, MacKenzie, I., Workman, A.J.   +5 more
core   +1 more source

Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice

Frontiers in Neuroscience, 2019
ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and central nervous
Cole Fisher, Kayla Johnson, Travis Okerman, Taylor Jurgenson, Austin Nickell, Erin Salo, Madelyn Moore, Alexis Doucette, James Bjork, Amanda H. Klein   +9 more
doaj   +1 more source

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

eLife, 2020
Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+
Samuel G Usher, Frances M Ashcroft, Michael C Puljung   +2 more
doaj   +1 more source