Results 141 to 150 of about 9,762 (266)

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt [PDF]

, 2017
Background The developmental transition from depolarizing to hyperpolarizing γ-aminobutyric acid-mediated neurotransmission is primarily mediated by an increase in the amount of the potassium-chloride cotransporter KCC2 during early postnatal life ...
Bodogan, T., Fiumelli, H., Hemmings, H. C., Hemmings, H. C., Kaila, K., Lacoh, C.-M, Vutskits, L.   +6 more
core  

Interleukin-1 receptor type 1 is over-expressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant induced inflammatory pain [PDF]

, 2017
K
Antal, Miklós, Bakk, Erzsébet, Bardóczi, Zsuzsanna, Ducza, László, Dócs, Klaudia, Hegedűs, Krisztina, Hegyi, Zoltán, Holló, Krisztina, Kis, Gréta, Mészár, Zoltán Mihály, Papp, Ildikó   +10 more
core   +1 more source

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

EBioMedicine, 2018
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic ...
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss   +7 more
doaj  

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Neurobiology of Disease, 2020
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV.
Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp   +3 more
doaj  

KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Acta Neuropathologica Communications, 2019
Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’
Lisa Hinz, Joan Torrella Barrufet, Vivi M. Heine   +2 more
doaj   +1 more source

The Neuron-specific K-Cl Cotransporter, KCC2 [PDF]

, 1999
Jeffery Williams, James W. Sharp, Vijaya Kumari, Martin Wilson, John A. Payne   +4 more
openalex   +1 more source

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

Cell Reports Medicine, 2023
R. Jarvis, Shu Fun Josephine Ng, Anna J. Nathanson, R. Cardarelli, Krithika Abiraman, Fergus Wade, Aidan Evans-Strong, Marina P. Fernandez-Campa, Tarek Z. Deeb, Joshua L. Smalley, Tanguy Jamier, I. Gurrell, Lisa McWilliams, A. Kawatkar, Leslie C. Conway, Qi Wang, R. Burli, N. Brandon, I. Chessell, Aaron J. Goldman, J. L. Maguire, S. Moss   +21 more
semanticscholar   +1 more source

Heterogeneous Expression of the Potassium-Chloride Cotransporter KCC2 in Gonadotropin-Releasing Hormone Neurons of the Adult Mouse [PDF]

, 2003
Sarah Leupen, Stuart A. Tobet, W F Crowley, Kai Kaila   +3 more
openalex   +1 more source

Treating Autism with Bumetanide By Yehezkel Ben‐Ari, Éric Lemonnier, Nouchine Hadjikhani, Cambridge scholars publishing. 2023. pp. 105

Acta Paediatrica, Volume 113, Issue 10, Page 2197-2198, October 2024.
Elisabeth Fernell
wiley   +1 more source

Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 [PDF]

, 2004
Claudio Rivera, Juha Voipio, Judith Thomas-Crusells, Hong Li, Zsuzsa Emri, Sampsa T. Sipilä, John A. Payne, Liliana Minichiello, Märt Saarma, Kai Kaila   +9 more
openalex   +1 more source