Results 151 to 160 of about 5,952 (193)

How hypoxia-induced diabetes develops and is maintained in children born preterm. [PDF]

Front Endocrinol (Lausanne)
Pae EK, Harper RM.
europepmc   +1 more source

Focal cortical dysplasias: modeling pediatric drug-resistant epilepsy using human brain organoids. [PDF]

Front Cell Neurosci
Petralla S, Crocco E, Giustizieri M, De Palma L, Cremisi F, Cherubini E, Specchio N, Cattaneo A, Marinelli S.   +8 more
europepmc   +1 more source

Functionalized nanozyme delivery of a KCC2-activator conjugate for the promotion of functional recovery after acute spinal cord injury. [PDF]

Mater Today Bio
Zhao H, Lin S, Chen H, Li Y, Gao K, Mei X.   +5 more
europepmc   +1 more source

Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord. [PDF]

Dev Neurobiol
Baudat M, Joosten EAJ, Simons SHP, Hove DLAVD, Riemens RJM.   +4 more
europepmc   +1 more source

Maternal copper levels moderate the neuroprotective effect of zinc on early childhood development: evidence from a birth cohort and proteomic profiling. [PDF]

Front Nutr
Liu C, Zhang Z, Huang M, Cheng H, He C, Zhou L, Zhang Y, Zhang J, Wei S, Liang T, Yang X.   +10 more
europepmc   +1 more source

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

Frau R, Concas L, Braccagni G, Traccis F, Branca C, Salviati S, Serra V, Corridori E, Nardi G, Pasquini G, Landi S, Santoni M, Follesa P, Brandalise F, Puligheddu M, Melis M, Ratto GM, Scheggi S, Bortolato M.   +18 more
europepmc   +1 more source

Advancing the Paradigm of Temporal Lobe Epilepsy as a Network Disease: The Promise of Biomarkers and Targeted Disease Modification. [PDF]

Int J Mol Sci
Orbán-Kis K, Kelemen K, Kiss RJ, Gáll Z, Nagy ZA, Fehér A, Todor N, Szentes Á, Metz JE, Szilágyi T.   +9 more
europepmc   +1 more source

Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment [PDF]

Acta Pharmacologica Sinica, 2023
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain, and GABA binding to the GABAA receptor (GABAAR) regulates Cl- and ...
Sunday Solomon Josiah, Jinwei Zhang, Ke Ding   +2 more
exaly   +7 more sources

The role of KCC2 in hyperexcitability of the neonatal brain [PDF]

Neuroscience Letters, 2020
The hyperpolarizing activity of γ-aminobutyric acid A (GABAA) receptors depends on the intracellular chloride gradient that is developmentally regulated by the activity of the chloride extruder potassium (K) chloride (Cl) cotransporter 2 (KCC2). In humans and rodents, KCC2 expression can be detected at birth.
Srdjan M Joksimovic, Dayalan Sampath, Slobodan M Todorovic   +2 more
exaly   +3 more sources