Results 131 to 140 of about 3,950 (160)

The KDM6B mutation: Phenotype and clinical characteristics—Report of a case

Revista de Psiquiatría y Salud Mental (English Edition), 2022
Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders. Until now, there are few cases in the literature attributed to KDM6B mutations. This gap may be due to the fact that the exome sequencing technique is still being implemented in routine clinical ...
Inmaculada, Insa Pineda, Cristina Luz, Gómez González   +1 more
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KDM6B (JMJD3) and its dual role in cancer

Biochimie, 2021
Epigenetic modifications play a fundamental role in the regulation of gene expression and cell fate. During the development of cancer, epigenetic modifications appear that favor cell proliferation and migration, but at the same time prevent differentiation and apoptosis, among other processes.
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Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

Nature Cancer, 2023
Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram the functional phenotype of immune-suppressive myeloid cells to overcome resistance to ICT remains unexplored.
Sangeeta Goswami, Deblina Raychaudhuri, Pratishtha Singh, Seanu Meena Natarajan, Yulong Chen, Candice Poon, Mercedes Hennessey, Aminah J. Tannir, Jan Zhang, Swetha Anandhan, Brittany Parker Kerrigan, Marc D. Macaluso, Zhong He, Sonali Jindal, Frederick F. Lang, Sreyashi Basu, Padmanee Sharma   +16 more
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TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment [PDF]

Cellular and Molecular Life Sciences, 2020
The acquisition of cell identity is associated with developmentally regulated changes in the cellular histone methylation signatures. For instance, commitment to neural differentiation relies on the tightly controlled gain or loss of H3K27me3, a hallmark of polycomb-mediated transcriptional gene silencing, at specific gene sets.
Amandine Charras, Charles Hong, C Joana Marques   +2 more
exaly   +5 more sources

Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration

2023
Abstract Epigenetic regulation of neuronal transcriptomic landscape is emerging to be a key coordinator of mammalian neural regeneration. Here we investigated roles of two histone 3 lysine 27 (H3K27) demethylases Kdm6a/b in controlling neuroprotection and axon regeneration.
Shu-Guang Yang, Xue-Wei Wang, Chang-Ping Li, Tao Huang, Cheng Qian, Qiao Li, Ling-Rui Zhao, Si-Yu Zhou, Chen-Yun Ding, null Saijilafu, Chang-Mei Liu, Feng-Quan Zhou   +11 more
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Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α [PDF]

Acta Biochimica Et Biophysica Sinica, 2015
Lysine (K)-specific demethylase 6B (KDM6B) is a histone H3K27 demethylase, which specifically catalyzes the demethylation of H3 lysine-27 tri/dimethylation (H3K27me3/2). KDM6B can activate gene transcription by promoting transcriptional elongation which is associated with RNA polymerase II and related elongation factors.
Weiren Huang, Xiaoqiang Guo
exaly   +4 more sources

KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells [PDF]

International Journal of Oral Science, 2013
Mesenchymal stem cells (MSCs) have been identified and isolated from dental tissues, including stem cells from apical papilla, which demonstrated the ability to differentiate into dentin-forming odontoblasts. The histone demethylase KDM6B (also known as JMJD3) was shown to play a key role in promoting osteogenic commitment by removing epigenetic marks ...
Cun-Yu Wang, Christine Hong, Juan Xu
exaly   +5 more sources

Kdm6b regulates cartilage development and homeostasis through anabolic metabolism

Annals of the Rheumatic Diseases, 2017
Epigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development. Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms.We screened the expression of 17 distinct histone demethylases by quantitative real time PCR (qRT-PCR) during chondrogenic ...
Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang   +10 more
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Macrophage Kdm6b Controls the Pro-Fibrotic Transcriptome Signature of Foam Cells

Epigenomics, 2017
In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells.Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencing analysis.Pathway analysis revealed that pro-fibrotic ...
Neele, Annette E, Prange, Koen HM, Hoeksema, Marten A, van der Velden, Saskia, Lucas, Tina, Dimmeler, Stefanie, Lutgens, Esther, Van den Bossche, Jan, de Winther, Menno PJ   +8 more
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Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling

Molecular Neurobiology, 2015
The transforming growth factor-β (TGF-β) family member activin A exerts multiple neurotrophic and protective effects in the brain. Activin also modulates cognitive functions and affective behavior and is a presumed target of antidepressant therapy. Despite its important role in the injured and intact brain, the mechanisms underlying activin effects in ...
Link, Andrea S, Kurinna, Svitlana; id_orcid 0000-0002-2157-667X, Havlicek, Steven, Lehnert, Sandra, Reichel, Martin, Kornhuber, Johannes, Winner, Beate, Huth, Tobias, Zheng, Fang, Werner, Sabine, Alzheimer, Christian   +10 more
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