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Design and synthesis of novel quinazoline derivatives as KDM6B selective inhibitors
Molecular DiversityThe abnormal function of histone lysine demethylase 6B (KDM6B) is closely associated with the development and progression of various human diseases, including cancer, inflammatory disorders, and psychiatric conditions, supporting KDM6B as a significant therapeutic target.
Dongxuan, Ni +8 more
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Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade
2022Abstract Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram the functional phenotype of immune-suppressive myeloid cells to overcome resistance to ICT remains unexplored.
Sangeeta Goswami +15 more
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[Study on the Expression of KDM6B of Osteoblast in Diabetic Environment].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2019To investigate the ability of osteogenic differentiation and the expression of histone demethylases KDM6B in bone marrow mesenchymal stem cells (BMSCs) in diabetic environment.Diabetic model rats was successfully established, and BMSCs from diabetic model rats and normal rats were isolated and cultured for further study.
Yu, Tang +5 more
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Histone demethylase KDM6B regulates human podocyte differentiation in vitro
Biochemical Journal, 2019Abstract Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role in podocyte differentiation is less understood.
Yanyan Guo, Zuying Xiong, Xiaoqiang Guo
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The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer
Annals of Surgical Oncology, 2015Jumonji-domain containing 3 (JMJD3) affects transcriptional regulation by demethylating lysine 27 residue of histone 3. We investigated its function and prognostic significance in colorectal cancer (CRC).The influence of JMJD3 on cell proliferation was assessed using quantitative RT-PCR and western blot on the downstream target gene of JMJD3, in knock ...
Ryuma, Tokunaga +16 more
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KDM6B regulates M2 polarization of macrophages by modulating the stability of nuclear β-catenin
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2023Tianyu Shen, Bo Dai, Xiaoyue Tan
exaly
KDM6B-mediated reprogramming of myeloid cells regulates the response to immunotherapy
Nature Cancer, 2023openaire +2 more sources