Results 1 to 10 of about 32,637 (272)
Parasites & Vectors, 2022 Background The Aedes aegypti mosquito is the primary vector for dengue, chikungunya, yellow fever and Zika viruses worldwide. The first record of Ae. aegypti in southwestern Saudi Arabia was in 1956.
Abadi M. Mashlawi +9 more
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Familial pulmonary arterial hypertension byKDRheterozygous loss of function [PDF]
European Respiratory Journal, 2020 Beyond the major gene BMPR2, several new genes predisposing to PAH have been identified during the last decade. Recently, preliminary evidence of the involvement of the KDR gene was found in a large genetic association study.
Mélanie Eyries +11 more
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PLOS Neglected Tropical Diseases, 2020 Aedes aegypti is the primary vector of dengue, chikungunya, Zika, and urban yellow fever. Insecticides are often the most effective tools to rapidly decrease the density of vector populations, especially during arbovirus disease outbreaks. However, the intense use of insecticides, particularly pyrethroids, has selected for resistant mosquito ...
Luciano Veiga Cosme +4 more
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A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegypti, co-occurring with F1534C, S989P and V1016G [PDF]
Parasites & Vectors, 2020 Aedes aegypti is a primary vector of dengue, chikungunya and Zika infections in India. In the absence of specific drugs or safe and effective vaccines for these infections, their control relies mainly on vector control measures.
Raja Babu Singh Kushwah +5 more
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The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway
Brazilian Journal of Medical and Biological Research, 2019 The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients ...
Jian Xia Chen +3 more
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First report of V1016G and S989P knockdown resistant (kdr) mutations in pyrethroid-resistant Sri Lankan Aedes aegypti mosquitoes [PDF]
Parasites & Vectors, 2018 Background Dengue is a serious arboviral disease in Sri Lanka with a large number of dengue fever (DF) cases every year. Control of the primary vector Aedes aegypti depends upon larval habitat source reduction and insecticide application.
Sachini D. Fernando +5 more
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Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance [PDF]
Parasites & VectorsThe ongoing fight against mosquito-borne diseases such as dengue, Zika, and chikungunya is increasingly challenged by Aedes aegypti resistance to pyrethroid insecticides.
Javier Tognarelli +3 more
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Thienopyridine urea inhibitors of KDR kinase
Bioorganic & Medicinal Chemistry Letters, 2007 A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
H Robin, Heyman +19 more
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Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s. [PDF]
Malaria Journal, 2017 Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture.
Tarekegn A. Abeku +8 more
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Cell Adhesion & Migration, 2019 Dysfunction of vascular smooth muscle cells (VSMCs) mediates intracranial aneurysm (IA). KDR is reported to alleviate IA progression via promoting VSMC proliferation, while the upstream regulators are still unclear.
Yushe Wang +6 more
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