Results 151 to 160 of about 45,202 (305)

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source

Playing KEAP1-away [PDF]

Nature Chemical Biology, 2018
openaire   +2 more sources

Molecular Evolution of Keap1 [PDF]

Journal of Biological Chemistry, 2008
Li Li, Makoto Kobayashi, Hiroshi Kaneko, Yaeko Nakajima-Takagi, Yuko Nakayama, Masayuki Yamamoto   +5 more
openaire   +1 more source

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

, 2019
Summary: Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).
Cheong-Hee Chang, Hamid Rabb, Sekhar P. Reddy, Ajay Kumar, Yeung-Hyen Kim, Sanjeev Noel, Kalyani Pyaram   +6 more
core   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature [PDF]

BACKGROUND/AIM: The Kelch-like-ECH associated protein 1 (Keap1) is an integral component of the E3-ubiquitin ligase complex, which binds to Nuclear factor erythroid 2-related factor 2 (Nrf2) and facilitates its degradation by the 26S proteasome.
Çiftçi, H., Okuducu, C., Fujita, M., Kutlu, Y., Tavli, S., Gül, M., Sever, B., Otsuka, M., Yilmaz, M., Haliloğlu, T., Demirci, H., Yiǧit Kutlu, OKUDUCU, Ceren, TAVLI, Serra, Masami Otsuka, Haliloglu, Tuerkan, Mikako Fujita, Serra Tavli, DEMİRCİ, Hasan, Merve Yilmaz, KUTLU, Yiğit, Belgin Sever, OTSUKA, Masami, Mehmet Gül, GÜL, Mehmet, SEVER, Belgin, Hasan DeMi̇rci̇, FUJITA, Mikako, Halil I. Ciftci, Türkan Haliloğlu, Ceren Okuducu, ÇİFTÇİ, Halilibrahim, YILMAZ, Merve, HALİLOĞLU, Türkan   +33 more
core   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Chronic IL-1-Exposed LNCaP Cells Evolve High Basal p62-KEAP1 Complex Accumulation and NRF2/KEAP1-Dependent and -Independent Hypersensitive Nutrient Deprivation Response

Chronic inflammation is a cancer hallmark and chronic exposure to interleukin-1 (IL-1) transforms castration-sensitive prostate cancer (PCa) cells into more fit castration-insensitive PCa cells. p62 is a scaffold protein that protects cells from nutrient
Rafah Falah, Nikki A. Delk, Haley Dahl-Wilkie, Sammy Pardo, Susan Weintraub, Basir Mansoor, Jessica Gomez, Anastasia Kelley, Morolake Omiyale, Kirti Manjit, Anisha R. Konakalla, Preethi Kanumuri, Dana Molleur   +12 more
core   +1 more source

Biomimetic PB@PDA‐CA@Mem nanoplatform regulates oxidative stress and inflammatory microenvironment to enhance stroke recovery

VIEW, EarlyView.
PB@PDA‐CA@Mem enhances ischemic brain accumulation and enables acid‐responsive CA release. Through broad‐spectrum ROS/RNS scavenging, Nrf2/Keap1 activation, and NF‐κB/NLRP3 suppression, it alleviates oxidative stress and neuroinflammation, preserves neuronal architecture, reduces infarction, and improves functional recovery.
Lei Shi, Zhuonan Wang, Chenxi Zhou, Shuping Wang, Xuting Shen, Si Cheng, Yongli Yang, Nengrui Guo, Zhengrong Zhong, Lijun Bai   +9 more
wiley   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source