Results 151 to 160 of about 50,990 (303)

Characterization, Identification, and Antioxidant Mechanism of Antioxidant Peptides From <i>Schisandra chinensis</i> Based on Peptidome and Molecular Docking/Dynamics. [PDF]

Food Sci Nutr
Schisandra chinensis peptides (SCP) exhibited potent in vitro antioxidant activity and repaired UVB‐induced oxidative damage in HaCaT cells, while demonstrating excellent stability and biosafety. SCP also activated the Keap1/Nrf2 pathway, with IFSPWL identified as the key bioactive peptide that forms the most stable Keap1 complex via integrated ...
Zheng S, Xiao X, Li Y, Su T, Lv Q, Fang J, Hao L, Lu H.   +7 more
europepmc   +2 more sources

TARGETING THE NRF2/KEAP1 INTERACTION

, 2014
The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic ...
Steel, Richard James
core  

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Keap1 inhibition enhances degradation of the Aβ42 peptide.

, 2017
(A) Lowering Keap1 reduced total Aβ42 peptide levels in 14 day-old flies. Data are presented as means ± SEM.
Fiona Kerr (152866), Dobril K. Ivanov (3808930), Rebecca Callard (3808933), Inge Snoeren (3467951), Oyinkan Sofola-Adesakin (3467957), Janet Thornton (57501), Jennifer Adcott (3808945), Beatriz Gomez Perez-Nievas (3808927), Geoffrey Wells (297758), Helena M. Cochemé (3808939), Jorge Iván Castillo-Quan (3808942), Wendy Noble (3422765), Mobina Khericha (3467954), Jemma Gatliff (668598), Linda Partridge (1176477), Hélène C. Bertrand (3808936), Pedro Martinez (152873)   +16 more
core   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

Mutational and Expressional Analyses of NRF2 and KEAP1 in Sarcomas

, 2012
Aims and background Nuclear factor erythroid 2-related factor 2 (NRF2) activates expression of cytoprotective proteins such as GCLC and enhances cancer cell survival, whereas KEAP1 inhibits NRF2 by mediating NRF2 degradation. Somatic mutation of NRF2 and
Nam Jin Yoo, Eun Mi Mi Je, Chang Hyeok An, Sug Hyung Lee   +3 more
core   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

WDR23 regulates NRF2 independently of KEAP1.

, 2017
Cellular adaptation to stress is essential to ensure organismal survival. NRF2/NFE2L2 is a key determinant of xenobiotic stress responses, and loss of negative regulation by the KEAP1-CUL3 proteasome system is implicated in several chemo- and radiation ...
Brett N Spatola, Sean P Curran, Brett N. Spatola, Sean P. Curran, Jacqueline Y Lo, Jacqueline Y. Lo   +5 more
core   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source