Results 171 to 180 of about 53,484 (262)

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

KEAP1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

KEAP1 wt Allele [PDF]

, 2020
openaire   +1 more source

Oxidative Stress and the KEAP1/NRF2 Axis in Saphenous Vein: Implications for Graft Patency. [PDF]

Cells
Layton GR, Marston E, Musa HL, Ladak S, Copperwheat A, Oluwanifemi A, Antoun I, Zakkar M.   +7 more
europepmc   +1 more source

NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way. [PDF]

iScience
Qiu Z, Lin Y, Chen S, Cao W, Yang J, Li R, Chen Y, Yao X, Fu S, Jin N.   +9 more
europepmc   +1 more source

Investigating the Regulatory Mechanisms and Prognostic Significance of miR-941 Targeting the Nrf2/Keap1 Pathway in Elderly Ischemic Stroke Patients. [PDF]

Cell Mol Neurobiol
Huang X, Gao J, Zhu R, Sun Y, Zhang L, Gao X.   +5 more
europepmc   +1 more source

NRF2 as a Therapeutic Target in Dermatological Disorders: Mechanisms and Molecules. [PDF]

Pharmaceuticals (Basel)
Khiar-Fernández I, Khiar-Fernández N, Pereyra-Rodríguez JJ, Fernández I.   +3 more
europepmc   +1 more source

Lan enzyme-free construction of lanthionine-bridged macrocyclic phage libraries. [PDF]

Chem Sci
Yang F, Xiao J, Huang W, Gao J.
europepmc   +1 more source

Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation. [PDF]

Cell Biol Toxicol
Chen Y, Liu Y, Zhang M, Li S, Yan Y, Yin C.   +5 more
europepmc   +1 more source