Results 171 to 180 of about 35,325 (217)

KRAS G12C inhibitor outcomes in advanced non-small cell lung cancer by smoking history, performance status, and KEAP1 mutation status. [PDF]

Cancer Treat Res Commun
Xu Z, Aredo JV, Su CC, Myall NJ, Roy M, Ramchandran KJ, Wakelee HA, Neal JW.   +7 more
europepmc   +1 more source

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source

Asporin promotes gastric cancer progression by regulating NRF2 ubiquitination and competitively binding to KEAP1. [PDF]

Transl Cancer Res
Yin L, Du M, Ying J, Zhong X, Wang F, Zhang N, Chen Z.   +6 more
europepmc   +1 more source

Methotrexate Alters Nrf2/HO‐1 Protein Expression and Intrinsic Apoptosis‐Associated Protein Responses in OVCAR‐3 Ovarian Cancer Cells: Differential Modulation by Antioxidant Compounds

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Methotrexate (MTX) altered oxidative stress parameters, reduced Nrf2 and HO‐1 protein expression, increased intrinsic apoptosis‐associated protein markers, and decreased cell viability in OVCAR‐3 cells. Antioxidant co‐treatment partially modulated these protein responses and oxidative stress parameters.
Oya Korkmaz
wiley   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, Volume 65, Issue 8, Page 963-976, August 2026.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

Citrus Peel Xanthophylls Orchestrate Lipid–Glucose–Inflammation Axis Reprogramming in Cardiometabolic Syndrome: Integrative In Silico and In Vivo Evidence

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
Central obesity and dyslipidaemia converge to impair insulin signalling and trigger chronic inflammation, oxidative stress, and mitochondrial dysfunction. This integrated metabolic disruption drives lipid imbalance, apoptosis, and persistent hyperglycaemia, ultimately accelerating the progression of type 2 diabetes and cardiovascular disease.
Muhammad Reva Aditya, Muhammad Yusuf, Kanandya Kizzandy, Rizki Hari Mulia, Agnes Vianne, Athaya Rahmanardi Muhammad, Davina Shafa Aviantiputri, Adha Fauzi Hendrawan, Ade Meidian Ambari, Dante Saksono Harbuwono, Antonello Santini, Fahrul Nurkolis   +11 more
wiley   +1 more source

Investigating the Regulatory Mechanisms and Prognostic Significance of miR-941 Targeting the Nrf2/Keap1 Pathway in Elderly Ischemic Stroke Patients. [PDF]

Cell Mol Neurobiol
Huang X, Gao J, Zhu R, Sun Y, Zhang L, Gao X.   +5 more
europepmc   +1 more source

Integrative Identification of Anti‐Photoaging Peptides From Stress‐Tolerant Microorganisms via Machine Learning and KEAP1–NRF2 Docking

Journal of Peptide Science, Volume 32, Issue 8, August 2026.
Novel short‐chain peptides targeting the KEAP1‐NRF2 axis were identified through a multimodal discovery platform combining a stress‐tolerant microbial library with machine learning and molecular docking. These peptides regulate collagen synthesis and reduce MMP1/9 levels in human fibroblasts, providing significant protection against photoaging ...
Hanui Lee, Gyeong Han Jeong, Ji Wan Choi, Taehwan Kim, Younhee Shin, Jaewon Lim, Kwang‐Woo Jung, Byung Yeoup Chung, Seung Sik Lee   +8 more
wiley   +1 more source