Results 181 to 190 of about 50,990 (303)
Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis
Experimental Physiology, EarlyView.Abstract
There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.Chrysovalantis Stachteas, Nikolaos Georgogiannis, George G. Nastos, Panagiotis N. Chatzinikolaou, Petros C. Dinas, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Athanasios Z. Jamurtas, Ioannis G. Fatouros, Michalis G. Nikolaidis, Nikos V. Margaritelis +12 morewiley +1 more sourceRo5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis
The Journal of Physiology, EarlyView.Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer +7 morewiley +1 more sourceAntioxidant potential of Mexican edible flowers: In vitro characterization, KEAP1-NRF2 docking, and ADME/T predictions
[EN] Mexican edible flowers have enormous gastronomic and cultural value, but their potential as functional ingredients remains largely unexplored. Although the antioxidant properties of phenolic compounds are well documented, limited information is ...Castañeda-Rodríguez, Rey, Quiles Chuliá, Mª Desamparados, Quiñones-Muñoz, Tannia Alexandra, Ozuna, Cesar, Diaz-Cervantes, Erik +4 morecore +1 more sourceAntioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres
The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas +12 morewiley +1 more sourceBorn early, age fast: Consequences of premature birth on chronic disease and accelerated ageing
The Journal of Physiology, EarlyView.Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani +5 morewiley +1 more sourcePrediction of the individual risk for the development of brain metastases in patients with non‐oncogene‐addicted non‐small cell lung cancer: Real‐world data from the German prospective CRISP registry (AIO‐TRK‐0315)
International Journal of Cancer, Volume 159, Issue 3, Page 739-749, 1 August 2026.What's New?
Estimating the risk of developing brain metastases may enable earlier diagnosis and treatment, potentially reducing morbidity and mortality. Using the prospective CRISP lung cancer registry, the authors developed and validated a point‐based classifier for the risk of developing first brain metastases in patients with advanced or metastatic ...Fabian Acker, Katharina Wenger, Martin Reck, Cornelius F. Waller, Petra Hoffknecht, Andre Bethge, Arnd Nusch, Marcel Reiser, Christiane Bernhardt, Michael Bendel, Carolin Lennartz, Annette Fleitz, Martina Jänicke, Paula Ludwig, Annika Groth, Frank Griesinger, Michael Thomas, Wilfried E. E. Eberhardt, Martin Sebastian, for the CRISP Registry Group, Juliana Ababei, Jürgen Alt, Andreas Ammon, Sven Philip Aries, Akin Atmaca, Ivo Azeh, Eva‐Maria Barkowsky, Stefan Bauer, Silvan Becker, Dirk Behringer, Michael Bendel, Robin Benkelmann, Veronika Berberich, André Bethge, Annalen Bleckmann, Michael Boesche, Sabine Bohnet, Harald‐Robert Bruch, Wolfgang Brückl, Ulrike Burkhard‐Meier, Dieter Bürkle, Daniel C. Christoph, Petros Christopoulos, Peter Czyborra, Klaus‐Ulrich Däßler, Maike de Wit, Tobias Dechow, Reinhard Depenbusch, Karl‐Matthias Deppermann, Nicolas Dickgreber, Lutz Dietze, Markus Dommach, Steffen Dörfel, Wilfried Eberhardt, Ekkehard Eigendorff, Corinna Elender, Wolfgang Elsel, Till‐Oliver Emde, Bastian Eul, Martin Faehling, Florian Fauth, Thomas Fietz, Dimitri Flieger, Helmut Forstbauer, Werner Freier, Christian Frenzel, Florian Fuchs, Roswitha Fuchs, Thomas Fühner, Tobias Gaska, Wolfgang Gleiber, Tobias Graefe, Ullrich Graeven, Christian Grah, Sibylle Greiner, Frank Griesinger, Christian Grohé, Matthias Groschek, Carolin Groß‐Ophoff‐Müller, Andreas Günther, Sylvia Gütz, Siegfried Haas, Matthias Hackenthal, Volker Hagen, Carla Verena Hannig, Richard Hansen, Andrea Heider, David Heigener, Kathrin Heinrich, Natalia Heinz, Christiane Hering‐Schubert, Jörg Heßling, Conrad Heuchel, Petra Hoffknecht, Patricia Hortig, Gerdt Hübner, Horst‐Dieter Hummel, Ulrich Hutzschenreuter, Gerald Illerhaus, Thomas Illmer, Georg Innig, Melanie Janning, Jan Janssen, Christian Junghanß, Christian Kaes, Ulrich Kaiser, Stefan Kaldune, Haytham Kamal, Kato Kambartel, Lale Kayikci, Jens Kern, Dorothea Kingreen, Ortwin Klein, Konrad Kokowski, Wolfgang Körber, Dirk Koschel, Benoit Krämer, Beate Krammer‐Steiner, Jonas Kuon, Eckart Laack, Christof Lamberti, Markus Lehmann, Rumo David Leistner, Rüdiger Liersch, Hartmut Linde, Migle Link, Jörg Lipke, Verena Luber, Andreas Lück, Gita Maher, Kerstin Martin, Martin Metzenmacher, Christian Meyerzum Büschenfelde, Philipp Meyn, Enno Moorahrend, Christian Mozek, Annette Müller, Lothar Müller, Michael Neise, Holger Nückel, Arnd Nusch, Tobias Overbeck, Matthias Paland, Henning Pelz, Volker Petersen, Bettina Peuser, Christian Plate, Margarete Plath, Stefan Pluntke, Munir Rababah, Martin Reck, Niels Reinmuth, Marcel Reiser, Roland Repp, Daniel Reschke, Achim Rittmeyer, Yolanda Rodemer, Georg Rußwurm, Parvis Sadjadian, Reiner Sandner, Annette Sauer, Harald Schäfer, Clemens Schiefer, Burkhard Schmidt, Stephan Schmitz, Folker Schneller, Jan Schröder, Gunter Schuch, Christoph Schulz, Christian Schulz, Mathias Schulze, Christian Schumann, Wolfgang Schütte, Martin Schwaiblmair, Marcus Schweigert, Peter Florian Schwindt, Martin Sebastian, Bernd Seese, Gernot Seipelt, Christoph Sick, Theodoros Skentos, Thomas Sorgenfrei, Axel Stang, Johannes Steiff, Heike Steiniger, Susanne Stetter, Runa Stiegler, Heidrun Stumme, Amanda Tufman, Jens Uhlig, Ursula Vehling‐Kaiser, Gunther Vogel, Eyck von der Heyde, Oliver Waidmann, Cornelius F. Waller, Georg Weißenborn, Florian Weißinger, Martin Wermke, Claas Wesseler, Jörg Wiegand, Ute Wieschermann, Stefan Wilhelm, Jochen Wilke, Mark‐Oliver Zahn, Matthias Zaiss, Matthias Zeth, Joachim Zimber, Björn Schöttker +207 morewiley +1 more sourceChemical Biological Probes of the KEAP1/NRF2 Interaction
, 2018 Kelch ECH-Associated Protein 1 (KEAP1) is an adaptor protein which functions as a negative regulator to Nuclear factor (erythroid-derived 2)-like 2 (NRF2). KEAP1 complexes NRF2 with the E3 ubiquitin ligase Cullin-3 (Cul3).Benjamin G Richardson (7983371)core
