Results 211 to 220 of about 50,990 (303)

Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [PDF]

Pharm Biol
Zhang X, Wang J, Zhou Y, Shen C, Yuan M, Li Q, Li W.   +6 more
europepmc   +1 more source

Tunable Bio‐Derived Bimetallic Cu–Zn/2‐AA Metal–Organic Framework as an Efficient Electrode Modifier for Detection of Cadmium and Dopamine

ChemElectroChem, Volume 13, Issue 11, 3 June 2026.
A bio‐derived bimetallic Cu–Zn/2‐AA metal–organic framework is developed as an efficient electrode modifier for dual electrochemical sensing. The platform delivers ultrasensitive detection of cadmium and dopamine with femtomolar to attomolar limits and enhanced selectivity. The synergistic metal centers and porous structure significantly improve charge
Fahmida Akter Sahara, Shishir Kumar Dey, Md. Arafat Ali, Md. Razu Ahmed, Md. Hridoy Ali, Zarin Tasnim Nijhum, Md. Khairul Amin, Sagar Kumar Dutta   +7 more
wiley   +1 more source

Nrf2 mRNA in the first trimester as a predictive biomarker for gestational diabetes mellitus. [PDF]

Endocr Connect
Zhong X, Li S, Liu X, Li Q, Shen P.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, Volume 16, Issue 6, Page 1150-1165, June 2026.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

USP7-mediated deubiquitination of the KEAP1-NRF2-HMOX1 axis enhances radioresistance in non-small cell lung cancer by suppressing ferroptosis. [PDF]

Oncogene
Tang J, Xu L, Gong Z, Chen L.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment. [PDF]

RSC Chem Biol
Dayalan Naidu S, Dikovskaya D, Walker JM, Yee CLJ, Cafferkey AJ, Tatsuno M, Feng J, Moore TW, Johnson T, Honda T, Wells G, Suzuki T, Yamamoto M, Dinkova-Kostova AT.   +13 more
europepmc   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Pyrimethamine Restores KEAP1-Mediated Degradation of Select NRF2 Mutants in Esophageal Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Xiong Z, Paiboonrungruang C, Wang H, Subramaniyan B, Bui-Linh C, Li Y, Li H, Wang MC, Spitz F, Chen X.   +9 more
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source