Results 221 to 230 of about 45,202 (305)

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation. [PDF]

MedComm (2020)
Dou YN, Hu H, Li Q, Wang G, Hou L, Liu J, Zheng B, Li Y, Hu G, Fei Z, Li X, Wang L, Wei J, Jiang L, Fei X.   +14 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

IL15.3, a synthetic antimicrobial peptide, attenuates LPS-induced inflammatory responses in RAW 264.7 macrophages via transcriptional and proteomic modulation. [PDF]

PLoS One
Boonmark C, Roytrakul S, Saengyotha F, Tankrathok A, Wanthong A, Daduang J, Daduang S, Chaveerach A, Jangpromma N.   +8 more
europepmc   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, Volume 183, Issue 22, Page 6704-6717, November 2026.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

Bidirectional crosstalk between the catalytic and moonlighting functions of human dipeptidyl peptidase 3: potential physiological implications. [PDF]

RSC Adv
Matić A, Šupljika F, Petohleb L, Tomašić Paić A, Kindl DC, Horvat G, Barbarić L, Oskomić M, Matovina M, Tomić A.   +9 more
europepmc   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

<i>Caenorhabditis elegans</i> as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer's Disease: Plant Bioactive Compounds and Therapeutic Translation. [PDF]

Int J Mol Sci
Bellver-Sanchis A, Ralchev NR, Romanska PR, Dyakova NK, Ivanova KI, Griñán-Ferré C, Marchev AS.   +6 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease. [PDF]

J Med Chem
Callahan JF, Davies TG, Bantscheff M, Bedard S, Boehm J, Booth-Genthe C, Concha N, Copley R, Davis A, Davis R, Eberhard D, Foley J, Flamberg P, Goodwin NC, Heightman TD, Katchur SR, Kerns JK, Kmett C, Kotzer CJ, Landis P, Li T, Meinhold D, Mülbaier M, Nie H, Osborn RR, Peakman TM, Peck B, Podolin PL, Sweitzer T, Yan H, Ward P, Werner T, Wolfe Iii LA, Woolford AJ, Wu Z, Sanchez Y, Rumsey WL.   +36 more
europepmc   +1 more source