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Design of permeability-optimized target-binding macrocycles <i>via</i> direct preference optimization. [PDF]
Chem SciSun H +5 more
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An Integrated Approach Combining Surface Plasmon Resonance Screening with Proteomics Enables Discovery of Natural Molecular Glue Degraders. [PDF]
JACS AuYang Y +10 more
europepmc +1 more source
NRF2: Master regulator of cellular homeostasis and therapeutic vulnerability in cancer. [PDF]
Redox BiolChen WT, McKee NW, Kuhnell D, Dodson M.
europepmc +1 more source
Cochlear Inflammatory Microenvironment in Age-Related Hearing Loss: Mechanisms and Recent Advances. [PDF]
Clin Interv AgingLi X, Wu Z, Zhou Q, Lin S.
europepmc +1 more source
Structural characterization of KEAP1 variants to guide the design of KEAP1-Nrf2 peptide inhibitors
, 2020 openaire +1 more source
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The KEAP1-NRF2 system and neurodegenerative diseases
Antioxidants & Redox Signaling, 2023Significance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). NF-E2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar (CNC) family that harbors a unique basic ...
Akira Uruno, Masayuki Yamamoto
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Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms
Archives of Biochemistry and Biophysics, 2014Baicalein, a major component of Scutellaria baicalensis Georgi (Huang Qin), is widely used in the traditional Chinese medicine. However, the mechanisms underlying cancer chemoprevention are still not clear. The present study aimed to clarify how baicalein modulate Nrf2/Keap1 system to exert its cytoprotection and cancer chemoprevention. In the upstream
Si, Qin +6 more
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