Results 241 to 250 of about 45,202 (305)

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 2001-2013, October 2026.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

Targeting DPP9 attenuates podocyte injury by regulating NRF2 antioxidant signaling. [PDF]

Front Pharmacol
Cui C, Wei S, Zhang J, Xu J, Naimova S, Li Y, Wang H, Wang Y, Si R, Wei L, Lei F, Yu X, Liu P, Fu R.   +13 more
europepmc   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, Volume 103, Issue 10, Page 1211-1235, October 2026.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Kaempferol Alleviates Aflatoxin B1-Induced Liver Injury by Mitigating Oxidative Stress. [PDF]

Nutrients
Shu Z, Zhou Q, Zhu M, Yang L, Chen Y, Zhang Y, Bi J, Li W, Li M.   +8 more
europepmc   +1 more source

Molecular Mechanisms and Therapeutic Advances in KRAS G12C‐Mutant Non‐Small Cell Lung Cancer: Toward Mechanism‐Guided Longitudinal Management

Cancer Innovation, Volume 5, Issue 5, October 2026.
This review summarizes the molecular mechanisms, clinical development, resistance patterns, and emerging treatment strategies of KRAS G12C‐mutated non‐small cell lung cancer, with emphasis on approved inhibitors, combination approaches, next‐generation agents, and future directions from both global and Chinese perspectives.
Haiying Wang, Hanxiao Chen, Sheng Li, Jun Zhao   +3 more
wiley   +1 more source

NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formaldehyde tolerance in cancer. [PDF]

Sci Adv
Morellato AE, Alquezar-Artieda N, Guerrero-Maldonado A, Singh R, Beja L, Umansky C, Perich-Pallaruelo L, Pellicer M, Fernandez-Deu P, Aira N, Bourached-Silva N, Chorostecki U, Jones DJL, Roué G, Hopkinson RJ, Pontel LB.   +15 more
europepmc   +1 more source

Driver Gene Mutations Reprogram Lipid Metabolism in Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Non‐small cell lung cancer (NSCLC) is among the leading causes of cancer‐related deaths worldwide. Previous treatment regimens often have limited efficacy due to drug resistance and recurrence. Metabolic reprogramming participates in the initiation and progression of NSCLC, with prominent changes in lipid metabolism.
Jinxing Lin, Zhonghao Pang, Zhihua Jiang, Feng Li   +3 more
wiley   +1 more source

CRISPR/Cas9 screen identifies DCAF4 as a novel protector of hepatocellular carcinoma against brachytherapy via stress granule-dependent NRF2 activation. [PDF]

Cell Death Dis
Huang T, He Y, Wang X, Liu Z, Qiao E, Sun T, Mei J, Dai S, Wang Z, Feng C, Cao H, Wang Y, Xia Y, Liu E, Guo J, Lu J.   +15 more
europepmc   +1 more source