Results 251 to 260 of about 45,202 (305)

Targeting the Tumor Microenvironment Network to Overcome Immunotherapy Resistance in Non‐Small Cell Lung Cancer: Mechanisms to Clinical Translation

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Immunotherapy has transformed the treatment landscape for advanced non‐small cell lung cancer (NSCLC), yet resistance mediated by the tumor microenvironment (TME) limits its efficacy in most patients. This review aims to synthesize the current understanding of the TME as an integrated network driving immunotherapy resistance and to ...
Zengrui Wang, Zhuang Luo, Le Wang, Jiefu Tang, Zhi Zhang, Xinli Fan   +5 more
wiley   +1 more source

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling. [PDF]

Redox Biol
Deng Y, Xu L, Niu X, Li J, Xiong Y, Zhu G, Lu Z, Xu C, Wang X, Wang P, Huang J, Xiao Z, Gonzalez FJ, Ji L, Sun C, Wang P, Ge G.   +16 more
europepmc   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source

Decreased FSP1 expression under chronic hypoxia sensitizes human macrophages towards ferroptosis. [PDF]

Redox Biol
Wickert A, Schwantes A, Shadid Y, Meyer SP, Brüne B, Fuhrmann DC.   +5 more
europepmc   +1 more source

Ethnomedicinal and Phytopharmaceutical Properties of Syzygium samarangense (Blume) Merr. & L.M. Perry: A Gateway to Future Drug Development

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ABSTRACT Recently, natural products and plant‐based regimens are widely recognized as potential complementary and alternative therapeutic solutions. Traditionally, ethnomedicinal knowledge, validated through scientific evidence, has been a basis for modern drug discovery, emphasizing the importance of updated phytopharmacological knowledge of medicinal
Sujit Kumar Patro, Rudra Narayan Sahoo, Ashirbad Nanda, Shasank S. Swain   +3 more
wiley   +1 more source

A ZIP-Active Tumor Cell State Defines an NRF2-Associated Ferroptosis-Resistant and Immune-Cold Transcriptional Program in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Takahashi H, Uchida M, Takahashi K, Hagiwara H, Tada H, Matsuyama T, Chikamatsu K.   +6 more
europepmc   +1 more source

Ellagic Acid Enhances RSL3-Induced Ferroptosis by Inhibiting the Nrf2/HO-1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma. [PDF]

FASEB J
Bai J, Dai Y, Ein Oon C, Hu P, Luo J, Han J, Yang L, Bostani A, Fei Z, Jin Y.   +9 more
europepmc   +1 more source

Correction: Kummerowia striata extract protects paracetamol-induced liver injury by modulating the S1P/Nrf2/Keap1 pathway. [PDF]

PLoS One
Qin H, Chen R, Xie Y, Liu H, Xiao Y, Li L.   +5 more
europepmc   +1 more source

Dysregulated m⁶A via compensatory arginine methylation primes premalignancy in metabolic dysfunction-associated steatotic liver disease. [PDF]

Sci Adv
Kim GD, Choi D, Kim SY, Jeong H, Kang G, Eom SJ, Eom S, Park J, Lee HS, Yang I, Sung JK, Nam KT, Park YN, Chi SW, Koo SH.   +14 more
europepmc   +1 more source