Results 261 to 270 of about 45,202 (305)

The KEAP1-NRF2 system and neurodegenerative diseases

Antioxidants & Redox Signaling, 2023
Significance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Akira Uruno, Masayuki Yamamoto
openaire   +3 more sources

Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

Archives of Biochemistry and Biophysics, 2014
Baicalein, a major component of Scutellaria baicalensis Georgi (Huang Qin), is widely used in the traditional Chinese medicine. However, the mechanisms underlying cancer chemoprevention are still not clear. The present study aimed to clarify how baicalein modulate Nrf2/Keap1 system to exert its cytoprotection and cancer chemoprevention. In the upstream
Si, Qin, Fangming, Deng, Weiguo, Wu, Liwen, Jiang, Takaaki, Yamashiro, Satoshi, Yano, De-Xing, Hou   +6 more
openaire   +2 more sources

Structural basis of Keap1 interactions with Nrf2

Free Radical Biology and Medicine, 2015
Keap1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the Cul3 protein to form a Cullin-RING E3 ligase complex for the degradation of Nrf2. Oxidative stress disables Keap1, allowing Nrf2 protein levels to accumulate for the transactivation of critical stress response genes.
Alex N Bullock, Fiona J Sorrell, Peter Canning   +2 more
exaly   +3 more sources

Keap1 in adhesion complexes

Cell Motility, 2003
AbstractCell adhesion complexes are sensors that interact with the extracellular environment and allow for the transmission of signals found outside the cell across the plasma membrane to the cell interior. Keap1 is a newly identified component of cell adhesion complexes.
Michaella, Velichkova, Tama, Hasson
openaire   +2 more sources