Results 281 to 290 of about 50,990 (303)

The KEAP1-NRF2 System and Neurodegenerative Diseases

Antioxidants and Redox Signaling, 2023
Significance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Nuclear factor erythroid 2–related factor 2
A. Uruno, Masayuki Yamamoto
semanticscholar   +1 more source

Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers.

European Journal of Pharmacology, 2023
Cervical and endometrial cancers are among the most dangerous gynaecological malignancies, with high fatality and recurrence rates due to frequent diagnosis at an advanced stage and chemoresistance onset.
G. Tossetta, D. Marzioni
semanticscholar   +1 more source

Keap1-independent Nrf2 regulation: A novel therapeutic target for treating kidney disease

Redox Biology
The transcription factor NF-E2-related factor 2 (Nrf2) is a master regulator of antioxidant responses in mammals, where it plays a critical role in detoxification, maintaining cellular homeostasis, combating inflammation and fibrosis, and slowing disease
Jiahui Zhang, Mingzhuo Zhang, Marc Tatar, Rujun Gong   +3 more
semanticscholar   +1 more source

Apoptotic Bodies Derived from Fibroblast‐Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR‐339‐5p/KEAP1/Nrf2 Axis

Advancement of science
Preventing and treating avascular necrosis at the distal end of the flaps are critical to surgery success, but current treatments are not ideal. A recent study shows that apoptotic bodies (ABs) generated near the site of apoptosis can be taken up and ...
Gaoxiang Yu, Yijie Chen, Ningning Yang, Haojie Zhang, Xuzi Zhang, Yibo Geng, Jiayi Zhao, Zhuliu Chen, Cheng-ji Dong, Lidan Lin, J. Qi, Xuanlong Zhang, Xiaoqiong Jiang, Weiyang Gao, Yuepiao Cai, Xiangyang Wang, Jian Ding, Jian Xiao, Kailiang Zhou   +18 more
semanticscholar   +1 more source

Molecular docking and molecular dynamics simulation of wheat gluten-derived antioxidant peptides acting through the Keap1-Nrf2 pathway.

The Journal of the Science of Food and Agriculture
BACKGROUND In our previous study, we successfully identified five peptides from wheat gluten: Ala-Pro-Ser-Tyr (APSY), Leu-Tyr (LY), Pro-Tyr (PY), Arg-Gly-Gly-Tyr (RGGY) and Tyr-Gln (YQ).
Wenying Liu, Rui Liu, Qingyu Qin, Hualei Wang, Xinxue Zhang, Ganlu Meng   +5 more
semanticscholar   +1 more source

Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers.

Drug resistance updates
Immunotherapy has revolutionized cancer treatment, yet the efficacy of immunotherapeutic approaches remains limited. Resistance to ferroptosis is one of the reasons for the poor therapeutic outcomes in tumors with Kelch-like ECH-associated protein 1 ...
Zhennan Yuan, Xueying Wang, Boyu Qin, R. Hu, Rui Miao, Yang Zhou, Lei Wang, Tong Liu   +7 more
semanticscholar   +1 more source

Ponicidin Promotes Hepatocellular Carcinoma Mitochondrial Apoptosis by Stabilizing Keap1‐PGAM5 Complex

Advancement of science
Ponicidin is a diterpenoid with demonstrated antitumor activity in clinical trials. However, the specific function and mechanism of action against hepatocellular carcinoma (HCC) remain unknown.
Bixin Zhao, Zuhui Liang, Lisheng Zhang, Lin Jiang, Yuanhang Xu, Ying Zhang, Rong Zhang, Caiyan Wang, Zhongqiu Liu   +8 more
semanticscholar   +1 more source

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

Annual Review of Pharmacology and Toxicology, 2007
T. Kensler, N. Wakabayashi, S. Biswal
semanticscholar   +1 more source

Exploring the target scope of KEAP1 E3 ligase-based PROTACs

Cell Chemical Biology, 2022
Inchul You
exaly  

Nrf2/Keap1/ARE signaling: Towards specific regulation

Life Sciences, 2022
Alexey V Ulasov, Andrey A Rosenkranz, Georgi Georgiev   +2 more
exaly