Results 311 to 320 of about 56,140 (348)
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling [PDF]
Nature, 2018 Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
Michael J Bollong +2 more
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The KEAP1-NRF2 system and neurodegenerative diseases
Antioxidants & Redox Signaling, 2023Significance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). NF-E2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar (CNC) family that harbors a unique basic ...
Akira Uruno, Masayuki Yamamoto
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Nrf2/Keap1/ARE signaling: Towards specific regulation
Life Sciences, 2022 The Nrf2 transcription factor governs the expression of hundreds genes involved in cell defense against oxidative stress, the hallmark of numerous diseases such as neurodegenerative, cardiovascular, some viral pathologies, diabetes and others. The main route for Nrf2 activity regulation is via interactions with the Keap1 protein. Under the normoxia the
Andrey A Rosenkranz +2 more
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Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms
Archives of Biochemistry and Biophysics, 2014Baicalein, a major component of Scutellaria baicalensis Georgi (Huang Qin), is widely used in the traditional Chinese medicine. However, the mechanisms underlying cancer chemoprevention are still not clear. The present study aimed to clarify how baicalein modulate Nrf2/Keap1 system to exert its cytoprotection and cancer chemoprevention. In the upstream
Si, Qin +6 more
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Cell Motility, 2003
AbstractCell adhesion complexes are sensors that interact with the extracellular environment and allow for the transmission of signals found outside the cell across the plasma membrane to the cell interior. Keap1 is a newly identified component of cell adhesion complexes.
Michaella, Velichkova, Tama, Hasson
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AbstractCell adhesion complexes are sensors that interact with the extracellular environment and allow for the transmission of signals found outside the cell across the plasma membrane to the cell interior. Keap1 is a newly identified component of cell adhesion complexes.
Michaella, Velichkova, Tama, Hasson
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Nature Cancer, 2020
KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.
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KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.
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Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction
Free Radical Biology and Medicine, 2016Nrf2-Keap1 system is a biological defense mechanism in response to various stressors. An inhibitor for Keap1-Nrf2 interaction to activate Nrf2 is expected as a novel target for drug discovery in oxidative stress-related disorders. However, Nrf2 is accumulated in many types of cancer and its expression is induced during the course of drug resistance ...
Daisuke Yasuda +14 more
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Cell Chemical Biology
In this issue of Cell Chemical Biology, Lu et al.1 report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models.
Jan, Gerhartz, Radosław P, Nowak
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In this issue of Cell Chemical Biology, Lu et al.1 report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models.
Jan, Gerhartz, Radosław P, Nowak
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Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice
Biochemical and Biophysical Research Communications, 2009Keap1 is proposed to be a sensor protein of electrophilic compounds and a transducer of the signal from electrophilic compounds for transcriptional activation. Thus, the use of keap1 gene-knockout (KO) mice is a straightforward approach in order to clarify the molecular background for the use of electrophilies as neuroprotective compounds.
Takumi, Satoh +5 more
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Nrf2:INrf2 (Keap1) signaling in oxidative stress [PDF]
Free Radical Biology and Medicine, 2009 Nrf2:INrf2 (Keap1) are cellular sensors of chemical- and radiation-induced oxidative and electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and coordinated induction of a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins.
James W, Kaspar +2 more
exaly +3 more sources