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Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2
Biochimie, 2019Keap1 is deemed as a suppressor of Nrf2 in cytoplasm by sequestrating Nrf2 to proteolysis as an adapter of the Cul3-Rbx1 E3 ubiquitin ligase complex. In the study, it was proposed that post-translational modification might affect the interaction between Nrf2 and Keap1, and the profiles of the phosphorylation of amino acid residues of Keap1 and its ...
Shuangshuang Wei +7 more
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Patenting perspective on Keap1 inhibitors (2019–2024)
Expert Opinion on Therapeutic PatentsKelch-like ECH-associated protein 1 (Keap1), an E3 ligase negatively regulating the nuclear factor erythroid 2-related factor 2 (Nrf2), has emerged as an auspicious drug target for treating ailments associated with oxidative stress and inflammation. Discovery of Keap1 inhibitors have attracted significant interest.This review covers patents on Keap1 ...
Yongfu, Luo +7 more
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KEAP1/NRF2 SIGNALING IN AGED BONE
Bone health is a critical element in mammalian quality of life. The Keap1/Nrf2 signaling pathway has recently been observed to be instrumental in a multitude of regulatory processes pertaining to cytoprotective gene expression, with growing evidence of its role in bone metabolism.openaire +1 more source
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
Molecular and Cellular Biology, 2020Liam Baird, Masayuki Yamamoto
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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Nature Reviews Drug Discovery, 2019, Geoffrey Wells, John D Hayes
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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nature Genetics, 2003Ken Itoh +2 more
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