Results 101 to 110 of about 21,045 (211)

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma [PDF]

, 2016
Cutaneous squamous cell carcinomas (cSCC) are the most common and highly mutated human malignancies, challenging identification of driver mutations and targeted therapies.
A Enomoto, A Kaulmann, A Kobayashi, A Orthwein, A Svobodova, AL Eggler, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, C Boesch-Saadatmandi, C Cavin, C Xu, D Ren, DD Zhang, DF Lee, EV Knatko, F Rolfs, GM DeNicola, HJ Prochaska, J Ma, K Itoh, K Itoh, K Le Gal, K Taguchi, M Marin-Kuan, M McMahon, M McMahon, M Ramos-Gomez, M Schafer, P Talalay, S Durinck, S Tao, S Vartanian, SB Cullinan, T Suzuki, TW Kensler, VI Sayin, WH Habig, Y Mitsuishi   +39 more
core   +2 more sources

Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway

Phytotherapy Research, EarlyView.
Under iron overload conditions, curcumin inhibits cellular senescence and promotes osteogenic differentiation by activating the NRF2/GPX4 signaling pathway in bone marrow mesenchymal stem cells (BMSCs), thereby preventing the onset of osteoporosis. ABSTRACT Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs ...
Jingmin Che, Qing Feng, Zhixia Zhao, Jingying Sun, Weihao Ren, Yangmeng Feng, Cuixiang Xu, Xu‐Hui Li   +7 more
wiley   +1 more source

An excess dietary vitamin E concentration does not influence Nrf2 signaling in the liver of rats fed either soybean oil or salmon oil [PDF]

, 2017
Background: Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body.
Eder, Klaus, Gessner, Denise K., Most, Erika, Scheibe, Susan, Siebers, Marina, Weissmann, Norbert   +5 more
core   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

Data from Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

, 2023
<div>Abstract<p>Loss-of-function mutations in the nuclear factor erythroid-2–related factor 2 (Nrf2) inhibitor Kelch-like ECH-associated protein 1 (Keap1) result in increased Nrf2 activity in non–small cell lung cancer and confer therapeutic resistance. We detected point mutations in <i>Keap1</i> gene, leading to nonconservative
Shyam Biswal, Steven G. Bova, Hailong Wu, Manish Bodas, Ponvijay Kombairaju, David Esopi, Srinivasan Yegnasubramanian, Anju Singh, Ping Zhang   +8 more
openaire   +1 more source

Human DPP III – Keap1 Interactions: A Combined Experimental And Computational study

Croatica Chemica Acta, 2016
Kelch-like ECH associated protein 1 (Keap1) is a cellular sensor for oxidative stress and a negative regulator of the transcription factor Nrf2. Keap1 and Nrf2 control expression of nearly 500 genes with diverse cytoprotective functions and the Nrf2 ...
Mario Gundić, Antonija Tomić, Rebecca C. Wade, Mihaela Matovina, Zrinka Karačić, Saša Kazazić, Sanja Tomić   +6 more
doaj   +1 more source

Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina [PDF]

, 2013
Oxidative stress is associated with diabetes me- llitus, a condition characterized by increased prevalence and progression rate of cardiovas-cular disease. NFE2-related factor 2 (Nrf2) is a master regulator of cellular detoxification re-sponses and redox
Gimenez, Maria Sofia, Gonzalez, Irma, Lucero, Roberto, Ojeda, Marta Susana, Santillán, Lucas Damián, Siewert, Susana   +5 more
core   +2 more sources

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

(1)H, (15)N and (13)C backbone resonance assignments of the Kelch domain of mouse Keap1. [PDF]

, 2012
Kelch-like ECH-associated Protein 1 (Keap1) is a multi-domain protein that functions as an inhibitor of the transcription factor nuclear factor E2-related factor 2 (Nrf2) in the cellular response to oxidative stress.
Choy, Wing-Yiu, Cino, Elio, Fan, Jingsong, Yang, Daiwen   +3 more
core   +3 more sources