Results 141 to 150 of about 21,045 (211)

RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2

Computational and Structural Biotechnology Journal
In this study, we proposed a novel comprehensive computational framework that combines deep generative modeling with in silico peptide optimization to expedite the discovery of bioactive compounds. Our methodology utilizes RFdiffusion, a variation of the
Francesco Morena, Chiara Cencini, Carla Emiliani, Sabata Martino   +3 more
doaj   +1 more source

Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1

Journal of Advanced Research
Introduction: Chronic obstructive pulmonary disease (COPD) represents a significant global health challenge, characterized by substantial morbidity and mortality rates. In traditional Chinese medicine (TCM), Farfarae Flos (FF) has been widely utilized as
Lin-Tao Xu, Qing-Tong Han, Zhen-Peng Xu, Xiao-Ning Wang, Hua Zhang, Tao Shen   +5 more
doaj   +1 more source

Unveiling Smyd-2’s Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion

Cells
SET and MYND Domain-Containing 2 (Smyd-2), a specific protein lysine methyltransferase (PKMT), influences both histones and non-histones. Its role in cerebral ischemia/reperfusion (CIR), particularly in ferroptosis—a regulated form of cell death driven ...
Daohang Liu, Yizhun Zhu
doaj   +1 more source

Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling

JACC: Basic to Translational Science
Summary: Hemodynamic shear stress is a frictional force that acts on vascular endothelial cells and is essential for endothelial homeostasis. Physiological laminar shear stress (LSS) suppresses endothelial inflammation and protects arteries from ...
Ruoyu Wang, MM, Yue Zeng, MM, Ziqi Chen, PhD, Dongwei Ma, MM, Xiaozhe Zhang, PhD, Guifu Wu, MD, PhD, Wendong Fan, PhD   +6 more
doaj   +1 more source

Aldose Reductase Defeciency Significantly Ameliorates Development of AngII-induced Hypertension in C57BL/6 mice [PDF]

, 2016
背景醛糖还原酶（Aldosereductase,AR)，作为山梨醇代谢通路（thepolyolpathway,PP）的限速酶，它的异常激活是导致糖尿病并发症的危险因素。先前的动物实验表明AR的抑制剂唑泊司他（zopolrestat）能显著预防糖尿病的并发症，而肾素-血管紧张素系统（therenin-angiotensinsystem/angiotensinII,RAS/AngII）控制水盐和血压平衡。但是，AR/PP与RAS/AngII之间是否存在相互作用并不清楚。在本论文中 ...
王光辉
core  

Kelch-Like ECH-Associated Protein 1 [PDF]

, 2020
openaire   +1 more source

Design, Synthesis, and Biological Evaluation of Naphthoquinone Salts as Anticancer Agents

Molecules
The Warburg effect, a unique glycolytic phenomenon in cancer cells, presents a promising target for developing selective anticancer agents. Previously, BH10, a hit compound disrupting glycolytic metabolism, was identified via phenotypic screening, with ...
Yao Cheng, Tsz Tin Yu, Ellen M. Olzomer, Kyle L. Hoehn, Frances L. Byrne, Naresh Kumar, David StC Black   +6 more
doaj   +1 more source

ZJ01, a Small Molecule Inhibitor of the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction, Reduces Hyperoxic Acute Lung Injury in a Mouse Model. [PDF]

Med Sci Monit, 2020
Wan J, Lin S, Huang X, Li Q, Zeng L, Du S.   +5 more
europepmc   +1 more source

Keap1 expression has independent prognostic value in pancreatic adenocarcinomas [PDF]

, 2015

core   +1 more source

Potential of rutin from <i>Rhizophora mucronata</i> leaves as a Inhibitor of Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2 Keap1/Nrf2): An <i>in silico</i> study for Alzheimer's therapy. [PDF]

J Adv Pharm Technol Res
Saputri LO, Permatasari L, Harahap HS, Rosyidi RM, Rivarti AW, Prihatina LM, Rahayu Z, Azariani W.   +7 more
europepmc   +1 more source