IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways [PDF]
Frontiers in Immunology, 2022 Keloid is an abnormal fibrotic disease after cutaneous injury characterized by exaggerated scar tissue formation, which often extends beyond the boundaries of the original wound.
Seon-Yeong Lee +10 more
doaj +3 more sources
The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models
Frontiers in Cell and Developmental Biology, 2020 Keloids constitute an abnormal fibroproliferative wound healing response in which raised scar tissue grows excessively and invasively beyond the original wound borders.
Grace C Limandjaja, Sue Gibbs
exaly +4 more sources
Keloid treatments: an evidence-based systematic review of recent advances [PDF]
Systematic Reviews, 2023 Background Keloids are pathologic scars that pose a significant functional and cosmetic burden. They are challenging to treat, despite the multitude of treatment modalities currently available.
Laura A. Walsh +6 more
openalex +2 more sources
Downregulation of β-catenin blocks fibrosis via Wnt2 signaling in human keloid fibroblasts [PDF]
Tumor Biology, 2017 Keloid is a disorder of fibroproliferative diseases that occurs in wounds, characterized by an exaggerated response to injury. The key factor responsible for the disease process has not been identified.
Yumei Cai +5 more
doaj +2 more sources
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation
JCI Insight, 2023 Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes ...
Hua Chao +10 more
doaj +2 more sources
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis
International Journal of Molecular Sciences, 2017 Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection.
Rei Ogawa,, Facs
exaly +2 more sources
Frontiers in Medicine, 2022 Keloid is a major type of skin fibrotic disease, with one prominent feature of extensive accumulation of extracellular matrix (ECM) components, and another feature of pain/itching, which is closely related to the peripheral nervous system (PNS). However,
Taogen Gong +8 more
doaj +2 more sources
Frontiers in Immunology, 2019 Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids display many cancer-like characteristics such as progressive ...
Nonhlanhla Khumalo, Ardeshir Bayat
exaly +2 more sources
Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis [PDF]
Plastic and Reconstructive Surgery, Global OpenBackground:. Keloids, benign skin tumors due to connective tissue overgrowth, can be exacerbated by ubiquitin-proteasome system abnormalities through uncontrolled inflammation.
Yeltai Nurzat, PhD +7 more
doaj +2 more sources
Identification and validation of CCR5 linking keloid with atopic dermatitis through comprehensive bioinformatics analysis and machine learning [PDF]
Frontiers in ImmunologyThere is sufficient evidence indicating that keloid is strongly associated with atopic dermatitis (AD) across ethnic groups. However, the molecular mechanism underlying the association is not fully understood.
Bin Zhou +17 more
doaj +2 more sources