Results 11 to 20 of about 22,847 (241)

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model

Experimental and Molecular Medicine, 2023
Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals.
A Ram Lee, Seon-Yeong Lee, Jeong Won Choi, In Gyu Um, Hyun Sik Na, Jung Ho Lee, Mi-La Cho   +6 more
doaj   +1 more source

Proton Nuclear Magnetic Resonance With Time-Frequency Analysis: A Potential Diagnostic Approach for Keloids. [PDF]

Int Wound J
ABSTRACT Keloids are chronic fibroproliferative skin disorders with high recurrence rates and limited treatment options, yet reliable diagnostic biomarkers are lacking. Current classification systems rely heavily on clinical observation, underscoring the need for objective, noninvasive tools.
Xia G, Dohi T, Hirakawa K, Okihara K, Hiruma E, Minagawa S, Abdelhakim M, Konta T, Terashi N, Kanawaku Y, Ogawa R.   +10 more
europepmc   +2 more sources

Punch Excision Combined With Radiotherapy for Keloid Treatment. [PDF]

J Cosmet Dermatol
ABSTRACT Background Punch excision is gaining recognition in keloid management. Its distinct mechanism from conventional surgery necessitates a re‐evaluation of the efficacy and safety when combined with radiotherapy (RT), an area currently lacking evidence.
Guan Y, Huang M.
europepmc   +2 more sources

Application of Brachytherapy in Postoperative Treatment of Keloid-Prone Patients. [PDF]

J Cosmet Dermatol
ABSTRACT Background Keloids are benign fibroproliferative tumors that often recur after surgical excision. Combining surgery with postoperative radiotherapy has emerged as a potential treatment strategy, though optimal radiotherapy protocols remain debated.
Tian H, Dai T, Yu C.
europepmc   +2 more sources

Massive ear keloids: Natural history, evaluation of risk factors and recommendation for preventive measures – A retrospective case series [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2017
Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians.  Genetics of this disorder continues to be obscure and poorly understood.
Michael Tirgan
doaj   +1 more source

Identification and characterization of four immune-related signatures in keloid

Frontiers in Immunology, 2022
A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined treatment. Existing evidence indicates that the immune system plays an important role in the occurrence and development of keloid.
Xiaoxiang Wang, Xiaoxiang Wang, Bo Liang, Jiehua Li, Xiaobing Pi, Peng Zhang, Xinzhu Zhou, Xiaodong Chen, Sitong Zhou, Ronghua Yang, Ronghua Yang   +10 more
doaj   +1 more source

Skin Cell Proliferation Stimulated by Microneedles [PDF]

, 2012
A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and ...
Kloth, Luther C., Liebl, Horst
core   +2 more sources

Botulinum Toxin A for the Treatment of Keloids [PDF]

, 2012
Introduction: Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity.
Bureik, D., Dombrowski, Yvonne, Gauglitz, Gerd, Pavicic, T., Ruzicka, Thomas, Schauber, Jürgen   +5 more
core   +1 more source

Secreted Factors from Keloid Keratinocytes Modulate Collagen Deposition by Fibroblasts from Normal and Fibrotic Tissue: A Pilot Study

Biomedicines, 2020
Interactions between keratinocytes and fibroblasts in the skin layers are crucial in normal tissue development, wound healing, and scarring. This study has investigated the role of keloid keratinocytes in regulating collagen production by primary ...
Mansour A. Alghamdi, Laith N. AL-Eitan, Andrew Stevenson, Nutan Chaudhari, Nicole Hortin, Hilary J. Wallace, Patricia L. Danielsen, Mitali Manzur, Fiona M. Wood, Mark W. Fear   +9 more
doaj   +1 more source

Expression of fibroblast-activation protein in keloid tissue and its clinical significance

Pifu-xingbing zhenliaoxue zazhi, 2020
Objective: To investigate the expression of fibroblast-activation protein(FAP) in keloid tissue and its role in the development of keloid. Methods: Immunochemical staining was used to evaluate the expression of FAP in 30 cases of keloid tissue (case ...
Yu-xiong ZOU, Ming-chun CHEN, Li-da XU
doaj   +1 more source