Results 21 to 30 of about 40,839 (332)

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model

Experimental and Molecular Medicine, 2023
Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals.
A Ram Lee, Seon-Yeong Lee, Jeong Won Choi, In Gyu Um, Hyun Sik Na, Jung Ho Lee, Mi-La Cho   +6 more
doaj   +1 more source

Single-cell RNA sequencing reveals distinct immunology profiles in human keloid

Frontiers in Immunology, 2022
Keloids, characterized by skin fibrosis and excessive accumulation of extracellular matrix, remain a therapeutic challenge. In this study, we systematically capture the cellular composition of keloids by the single-cell RNA sequencing technique.
Cheng Feng, Mengjie Shan, Yijun Xia, Zhi Zheng, Kai He, Yingxin Wei, Kexin Song, Tian Meng, Hao Liu, Yan Hao, Zhengyun Liang, Youbin Wang, Yongsheng Huang   +12 more
semanticscholar   +1 more source

Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression

Bioengineered, 2022
Keloids are an excessive tissue response to dermal damage, characterized by uncontrolled growth and a high recurrence rate after various treatments. Abnormalities with the extracellular matrix (ECM) are one of the most important contributing factors to ...
Jing Li, Zhiyu Li, Song Wang, Jianhai Bi, Ran Huo   +4 more
semanticscholar   +1 more source

Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis

Frontiers in Pharmacology, 2022
Keloids are fibroproliferative skin disorder caused by abnormal healing of injured or irritated skin and are characterized by excessive extracellular matrix (ECM) synthesis and deposition, which results in excessive collagen disorders and calcinosis ...
Fan Feng, Mingying Liu, Lianhong Pan, Jiaqin Wu, Chunli Wang, Li Yang, Wanqian Liu, Wei Xu, Mingxing Lei   +8 more
semanticscholar   +1 more source

Ideal Surgical Incision Lines Minimizing Tension: A Proposal Based on Observations of Hypertrophic Scars and Keloids. [PDF]

Plast Reconstr Surg Glob Open
Huang C, Quong WL, Kamii Y, Ogawa R.
europepmc   +2 more sources

Identification and characterization of four immune-related signatures in keloid

Frontiers in Immunology, 2022
A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined treatment. Existing evidence indicates that the immune system plays an important role in the occurrence and development of keloid.
Xiaoxiang Wang, Xiaoxiang Wang, Bo Liang, Jiehua Li, Xiaobing Pi, Peng Zhang, Xinzhu Zhou, Xiaodong Chen, Sitong Zhou, Ronghua Yang, Ronghua Yang   +10 more
doaj   +1 more source

Pruritus in Keloid Scars: Mechanisms and Treatments

Acta Dermato-Venereologica, 2021
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of
A. Hawash, G. Ingrasci, K. Nouri, G. Yosipovitch   +3 more
semanticscholar   +1 more source

Massive ear keloids: Natural history, evaluation of risk factors and recommendation for preventive measures – A retrospective case series [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2017
Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians.  Genetics of this disorder continues to be obscure and poorly understood.
Michael Tirgan
doaj   +1 more source

The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses

Frontiers in Immunology, 2022
Due to many inconsistencies in differentially expressed genes (DEGs) related to genomic expression changes during keloid formation and a lack of satisfactory prevention and treatment methods for this disease, the critical biomarkers related to ...
Yang Li, Min Li, Caijie Qu, Yongxi Li, Zhanli Tang, Zhike Zhou, Zengzhao Yu, Xu Wang, Linlin Xin, Tong-xin Shi   +9 more
semanticscholar   +1 more source

Skin Cell Proliferation Stimulated by Microneedles [PDF]

, 2012
A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and ...
Kloth, Luther C., Liebl, Horst
core   +2 more sources