Results 41 to 50 of about 22,847 (241)

Research progress in the pathogenesis of keloids

Pifu-xingbing zhenliaoxue zazhi, 2023
During the process of skin wound healing, hyperproliferation of fibroblasts and excessive deposition of collagen in the extracellular matrix lead to the formation of keloid, a benign tumor with characteristics of aggressive growth.
Kunpeng JIA, Jing ZHOU
doaj   +1 more source

Comparative dermatology [PDF]

, 2006
The authors show a case of keloid that is reminiscent of the bow-tie, a male piece of apparel.Os autores relatam um caso de quelóide que reporta à gravata borboleta, acessório de trajes em geral masculinos.Universidade Federal de Juiz de Fora Hospital ...
Fraga, Juliana Cristina Silva, Gamonal, Aloísio, Souza, Valdilene Loures De   +2 more
core   +5 more sources

IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation

JCI Insight, 2023
Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes ...
Hua Chao, Lisheng Zheng, Pojui Hsu, Jinyun He, Ridong Wu, Shuqia Xu, Ruixi Zeng, Yuan Zhou, Huisi Ma, Haibo Liu, Qing Tang   +10 more
doaj   +1 more source

Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden

Acta Dermato-Venereologica, 2023
Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan, Keunyoung Hur, Novi Kusumaningrum, Jin Ho Chung, Si-Hyung Lee, Je-Ho Mun   +5 more
doaj   +1 more source

Different therapeutic modalities in a patient with multiple spontaneously developed keloids: a case report [PDF]

, 2006
Keloids are benign tumors that usually develop as an excessive healing response to injury. They remain a challenging therapeutic problem to this day. Numerous treatment approaches are available, yet therapeutic results are often not satisfactory.
Bukvić-Mokos, Zrinka, Lipozenčić, Jasna, Marinović, Branka   +2 more
core  

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. [PDF]

, 2016
Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic ...
Addor, M.C., Adès, L.C., Bertola, D., Bohring, A., Brown, M.A., Carter, E., Cho, T.J., Daniel, P.B., Duba, H.C., Duncan, E.L., Fletcher, E., Hennekam, R.C., Jenkins, Z.A., Kim, C.A., Krakow, D., Leo, P., Markie, D.M., McInerney-Leo, A., Morava, E., Morgan, T., Neuhann, T., Robertson, S.P., Strom, T.M., Superti-Furga, A., Sutherland-Smith, A.J., Veenstra-Knol, I., Wade, E.M., Wieczorek, D., Wilkie, A.O., Wilson, L.C.   +29 more
core   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Quality of life in black African patients with keloid scars

Dermatology Reports, 2020
A keloid scar is a benign skin tumor and we aimed to assess the Quality of Life (QoL) of black Africans with keloid scars based on the Dermatology Life Quality Index (DLQI).
Komenan Kassi, Kanga Kouame, Alexandre Kouassi, Ange Allou, Isidore Kouassi, Sarah Kourouma, Elidje Ecra, Abdoulaye Sangare   +7 more
doaj   +1 more source

Gastrointestinal Manifestations in Rubinstein‐Taybi Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein–Taybi syndrome is a rare genetic condition associated with a wide range of physical, cognitive, and developmental impairments, yet its gastrointestinal manifestations remain poorly characterized. Case reports and small series suggest a high prevalence of gastroesophageal reflux, constipation, dysphagia, and nutritional compromise ...
Mohamad Abi Nassif, Ajay Kaul, Lev Dorfman, Khalil El‐Chammas   +3 more
wiley   +1 more source

Ferrostatin-1 inhibits fibroblast fibrosis in keloid by inhibiting ferroptosis [PDF]

PeerJ
Background Keloid is a chronic proliferative fibrotic disease caused by abnormal fibroblasts proliferation and excessive extracellular matrix (ECM) production.
Liu Yang, Xiuli Li, Yanli Wang
doaj   +2 more sources