Results 31 to 40 of about 3,241,173 (293)

cis regulation of the keratin 18 gene in transgenic mice. [PDF]

Molecular and Cellular Biology, 1993
The gene coding for human keratin 18 (K18), a type I intermediate filament protein found in a variety of simple epithelia, is regulated correctly in transgenic mice but is promiscuously expressed after direct transfection into cell culture lines. We have begun an investigation of the mechanisms responsible for the correct regulation of K18 with a ...
N S, Neznanov, R G, Oshima
openaire   +2 more sources

Identification and Mutational Analysis of the Glycosylation Sites of Human Keratin 18 [PDF]

Journal of Biological Chemistry, 1995
Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. We previously showed that K8/18 phosphorylation occurs on serine residues and that K8/18 glycosylation consists of O-linked single N-acetylglucosamines (O-GlcNAc) that are linked to Ser/Thr.
N O, Ku, M B, Omary
openaire   +2 more sources

Keratin intermediate filaments in the colon: guardians of epithelial homeostasis [PDF]

, 2020
Keratin intermediate filament proteins are major cytoskeletal components of the mammalian simple layered columnar epithelium in the gastrointestinal tract.
Heikkil�, Taina, Tayyab, Mina, Baghestani, Sarah, Toivola, Diana M., Nystr�m, Joel H., Alam, Catharina M., Polari, Lauri   +6 more
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Transcriptional Insulation of the Human Keratin 18 Gene in Transgenic Mice [PDF]

Molecular and Cellular Biology, 1993
Expression of the 10-kb human keratin 18 (K18) gene in transgenic mice results in efficient and appropriate tissue-specific expression in a variety of internal epithelial organs, including liver, lung, intestine, kidney, and the ependymal epithelium of brain, but not in spleen, heart, or skeletal muscle.
N, Neznanov, I S, Thorey, G, Ceceña, R G, Oshima   +3 more
openaire   +2 more sources

From Feather to Adsorbent: Keratin Extraction, Chemical Modification, and Fe(III) Removal from Aqueous Solution

Applied Sciences, 2021
In this work, feather keratin was extracted from the waste feather of chicken via alkyd pretreatment and reduction method, the extraction rate is above 85%. The molecular weight and aggregation morphology of feather keratin in an aqueous environment were
Sujuan Pan, Changqing Wang, Yibo Wang, Rongmin Wang   +3 more
doaj   +1 more source

A Composite Blood Biomarker Including AKR1B10 and Cytokeratin 18 for Progressive Types of Nonalcoholic Fatty Liver Disease [PDF]

Diabetes & Metabolism Journal
Background We aimed to evaluate whether composite blood biomarkers including aldo-keto reductase family 1 member B10 (AKR1B10) and cytokeratin 18 (CK-18; a nonalcoholic steatohepatitis [NASH] marker) have clinically applicable performance for the ...
Seung Joon Choi, Sungjin Yoon, Kyoung-Kon Kim, Doojin Kim, Hye Eun Lee, Kwang Gi Kim, Seung Kak Shin, Ie Byung Park, Seong Min Kim, Dae Ho Lee   +9 more
doaj   +1 more source

Complete structure of the gene for human keratin 18

Genomics, 1989
The complete sequence of the human keratin 18 (K18) gene was determined. The K18 gene is 3791 bp in length and the K18 protein is coded for by seven exons. The exon structure of K18 has been conserved compared to that of other keratin genes, with the exception of a single 3' terminal exon that codes for the tail domain of the protein that is ...
D A, Kulesh, R G, Oshima
openaire   +2 more sources

Mutation of human keratin 18 in association with cryptogenic cirrhosis. [PDF]

Journal of Clinical Investigation, 1997
Mutations in 11 of the more than 20 keratin intermediate filaments cause several epidermal and oral associated diseases. No disease-associated mutations have been described in keratin 8 or 18 (K8/18) which are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine.
N O, Ku, T L, Wright, N A, Terrault, R, Gish, M B, Omary   +4 more
openaire   +2 more sources

The molecular genetic analysis of the expanding pachyonychia congenita case collection [PDF]

, 2014
BackgroundPachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma (PPK) and nail dystrophy, often accompanied by oral leukokeratosis, cysts and follicular keratosis.
Wilson, N. J., Shepherd, A. A., Hansen, C. D., Sprecher, E., Milstone, L. M., McLean, W. H. I., Schwartz, M. E., Al-Asadi, E., Smith, F. J. D., O'Toole, E.   +9 more
core   +1 more source

Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17

, 2022
Impaired wound healing particularly in diabetics creates a significant healthcare burden. The study aimed to evaluate the effect of keratin-butyrate fibers (FKDP +0.1%NaBu) in a full-thickness skin wound model in 30 diabetic rats.
Mateusz Rybka (14011570), Emilia Samborowska (4683826), Bartłomiej Cieślik (5068253), Marek Konop (4405183), Piotr Konopelski (14011588), Łukasz Mazurek (14011573), Anna K. Laskowska (13885530), Adam Waszkowski (14011585), Robert A. Schwartz (3213558), Rafał Mazgaj (14011579), Zbigniew Ruszczak (14011576), Dorota Sulejczak (615690), Mateusz Szudzik (13965413), Jakub Frankowski (14011582), Joanna Czuwara (4405171)   +14 more
core   +1 more source