Results 71 to 80 of about 3,241,173 (293)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial)Research in context

EBioMedicine, 2019
Background: The POP Trial was a phase 1, open-label, rising-dose, randomised study that explored the safety and tolerability of calmangafodipir (superoxide dismutase mimetic) co-treatment with n-acetylcysteine (NAC) for paracetamol overdose.
Emma E. Morrison, Katherine Oatey, Bernadette Gallagher, Julia Grahamslaw, Rachel O'Brien, Polly Black, Wilna Oosthuyzen, Robert J. Lee, Christopher J. Weir, Dennis Henriksen, James W. Dear   +10 more
doaj   +1 more source

Wool-derived keratin dressings versus usual care dressings for treatment of slow healing venous leg ulceration: a randomised controlled trial (Keratin4VLU)

BMJ Open, 2020
Objective To determine the effect of a keratin dressing for treating slow-to-heal venous leg ulcers (VLU) on VLU healing.Design Pragmatic parallel group randomised controlled trial.Setting Community-dwelling participants.Participants People aged 18 or ...
Chris Bullen, Angela Wadham, Varsha Parag, Andrew Jull, Jill Waters, Carolina Weller   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Cytotoxic Potential of Rare Plant Salvia candidissima subsp. candidissima on Breast Cancer Cells

Brazilian Archives of Biology and Technology, 2023
Breast cancer is the leading cause of cancer-related deaths in women throughout the world. Research on natural anti-cancer products from plants has gained traction. Salvia L.
Elif Erturk, Omer Enes Onur, Ipek Aydin, Mustafa Zafer Ozel, Mehmet Firat, Ferda Ari   +5 more
doaj   +1 more source

Suppression of keratin 18 gene expression in bovine blastocysts by RNA interference

Reproduction, Fertility and Development, 2010
The expression of the cytoskeleton protein Keratin 18 (KRT18) starts at the onset of bovine blastocyst formation. KRT18 is solely expressed in the trophectoderm and can therefore be used as a marker for trophectodermal differentiation. In the present study, the expression of KRT18 was suppressed by RNA interference to probe its functional importance in
Goossens, Karen, Tesfaye, Dawit, Rings, Franca, Schellander, Karl, Hölker, Michael, Van Poucke, Mario, Van Zeveren, Alex, Lemahieu, Isabel, Van Soom, Ann, Peelman, Luc J.   +9 more
openaire   +3 more sources

Anaerobic Process for Biohydrogen Production using Keratin Degraded Effluent

, 2019
Fossil fuel energy depletion and removal of environmental wastes are big problem in many countries. Some of the wastes contain a considerable amount of protein and carbon compounds; little concentration is given to utilizing or recycling these wastes ...
Muthuramalingam Jothi Basu, Gujuluva Hari Dinesh, Kulanthaisamy Mohanrasu, Ramu Satheesh Murugan, Alagarsamy Arun, Nagarajan Arumugam   +5 more
core   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Soft epidermis of a scaleless snake lacks beta-keratin

European Journal of Histochemistry, 2009
Beta-keratins are responsible for the mechanical resistance of scales in reptiles. In a scaleless crotalus snake (Crotalus atrox), large areas of the skin are completely devoid of scales, and the skin appears delicate and wrinkled.
M Toni, L Alibardi
doaj   +1 more source

Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis [PDF]

Biochemical and Biophysical Research Communications, 2006
Phosphorylation and O-GlcNAcylation of keratin 18 (K18) are highly dynamic and involve primarily independent K18 populations. We used in vitro phosphorylation and O-GlcNAcylation of wild-type, phospho-Ser52, glyco-Ser48, and Ser-to-Ala mutant 17mer peptides (K18 amino acids 40-56), which include the major K18 glycosylation (Ser48) and phosphorylation ...
Guo-Zhong, Tao, Celeste, Kirby, Stephen A, Whelan, Frank, Rossi, Xiahui, Bi, Michael, MacLaren, Erik, Gentalen, Roger A, O'Neill, Gerald W, Hart, M Bishr, Omary   +9 more
openaire   +2 more sources