Results 91 to 100 of about 3,241,173 (293)
BiomedicinesBackground: Virtually the entire spectrum of liver disease is observed in association with type 2 diabetes mellitus (T2DM); indeed, T2DM is now the most common cause of liver disease in the U.S.
Leila Gobejishvili +6 more
doaj +1 more source
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality [PDF]
The EMBO Journal, 2000 It has been reported previously that keratin 8 (K8)-deficient mice of one strain die from a liver defect at around E12.5, while those of another strain suffer from colorectal hyperplasia. These findings have generated considerable confusion about the function of K8, K18 and K19 that are co-expressed in the mouse blastocyst and internal epithelia.
M, Hesse +4 more
openaire +2 more sources
Advanced Science, EarlyView.In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li +10 more
wiley +1 more source
O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression
, 2023 Abstract Glycosylation in human cholangiocarcinoma (CCA) actively contributes to pathophysiological steps of tumor progression. Of note is the dynamic modification of proteins by O-linked β-N-acetyl-glucosamine (O-GlcNAcylation) that modulates various tumor-associated biological activities. By using a cutting-edge chemical proteomic methodology
Ran Xie +10 more
openaire +1 more source
Nanomechanische Eigenschaften von Keratin 8/18 - von Einzelfilamenten zu Netzwerken
, 2012 The mechanical properties of epithelial cells are mainly determined by the cytoskeleton. The cytoskeleton consists of three different protein networks: microtubules, actin filaments and intermediate filaments.
Leitner, Anke
core +1 more source
In-situ development of self-defensive antibacterial biomaterials: phenol-g-keratin-EC based bio-composites with characteristics for biomedical applications [PDF]
, 2015 Recently, the development of highly inspired biomaterials with multi-functional characteristics has gained considerable attention, especially in biomedical, and other health-related areas of the modern world.
Kyazze, G. +9 more
core +1 more source
Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu +10 more
wiley +1 more source
Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing
Advanced Science, EarlyView.The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos +17 more
wiley +1 more source
Anaplasma phagocytophilum-Occupied Vacuole Interactions with the Host Cell Cytoskeleton
Veterinary Sciences, 2016 Anaplasma phagocytophilum is an obligate intracellular bacterial pathogen of humans and animals. The A. phagocytophium-occupied vacuole (ApV) is a critical host-pathogen interface.
Hilary K. Truchan +4 more
doaj +1 more source
The correlation of keratin expression with in-vitro epithelial cell line differentiation
, 2009 MPhil 2009 QMThe mechanism of transcriptional regulation which allows oral mucosal-specific expression of the human keratin 13 (K13) gene remains unknown.
Aden, Deeqo
core