Results 11 to 20 of about 5,007,575 (281)

Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization

Journal of Cell Science, 2007
Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle. We examined the contractile properties and morphology of fast-twitch skeletal muscle from mice lacking keratin 19.
Michele R, Stone, Andrea, O'Neill, Richard M, Lovering, John, Strong, Wendy G, Resneck, Patrick W, Reed, Diana M, Toivola, Jeanine A, Ursitti, M Bishr, Omary, Robert J, Bloch   +9 more
openaire   +3 more sources

Voiding symptoms aggravate with decreasing stromal/epithelial ratio and increasing glandular-epithelial content in patients undergoing laser enucleation for benign prostatic hyperplasia, independently from prostate size. [PDF]

PLoS ONE
IntroductionBenign prostatic hyperplasia (BPH) includes epithelial, stromal and mixed hyperplasia, but their specific contributions to voiding symptoms and prostate volume (PV) are unknown.
Patrick Keller, Sheng Hu, Wenbin Zhu, Yajie Xu, Laurenz Berger, Philip Nicola, Philipp Weinhold, Alexander Tamalunas, Christian G Stief, Martin Hennenberg   +9 more
doaj   +2 more sources

Keratin 19 as a Stem Cell Marker In Vivo and In Vitro

, 2004
The skin is a dynamic tissue in which terminally differentiated keratinocytes are replaced by the proliferation of new epithelial cells that will undergo differentiation. The rapid and continual turnover of skin throughout life depends on a cell population with unique characteristics: the stem cells.
Fortier, Kristine, Germain, Lucie, Larouche, Danielle, Hayward, Cindy Jean   +3 more
openaire   +4 more sources

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells. [PDF]

Proc Natl Acad Sci U S A
Abstract The exclusion of T cells causes immune escape of pancreatic ductal adenocarcinoma (PDA). T cell exclusion is mediated by the interaction between CXCR4 on T cells and its ligand, CXCL12, which is complexed to keratin-19 (KRT19) on the surface of PDA cells.
Moresco P, Kastan JP, Yang JI, Prabakar R, Kelley ZL, Minicozzi F, Adams DW, Cifani P, Tuveson DA, Fearon DT.   +9 more
europepmc   +5 more sources

Identification of Epithelial Stem Cells In Vivo and In Vitro Using Keratin 19 and BrdU

, 2009
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine. Based on their quiescent nature, the development of label retention assays allowed the localization of skin stem cells in the bulge region of the pilosebaceous units and in the bottom of rete ridges ...
Germain, Lucie, Larouche, Danielle, Paquet, Claudie, Simard-Bisson, Carolyne, Lavoie, Amélie   +4 more
openaire   +4 more sources

Keratin 19 is a potential diagnostic and prognostic biomarker in pancreatic adenocarcinoma. [PDF]

Medicine (Baltimore)
This study aimed to evaluate Keratin 19 (KRT19) as a potential prognostic biomarker for the diagnosis and prognosis of pancreatic adenocarcinoma (PAAD). Using data from The Cancer Genome Atlas and the Gene Expression Omnibus, we analyzed KRT19 expression in PAAD tissues and identified differentially expressed genes associated with KRT19. Gene ontology (
He L, Li L, Chen Z, Chen Z.
europepmc   +3 more sources

Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3. [PDF]

Mol Biol Cell, 2021
Abstract Cyclin D3 regulates the G1/S transition and is frequently overexpressed in several cancer types including breast cancer, where it promotes tumor progression. Here, we show that a cytoskeletal protein keratin 19 (K19) physically interacts with a serine/threonine kinase GSK3β and prevents GSK3β-dependent degradation of cyclin D3.
Sharma P, Tiufekchiev S, Lising V, Chung SW, Suk JS, Chung BM.   +5 more
europepmc   +5 more sources

The correlation of keratin expression with in-vitro epithelial cell line differentiation [PDF]

, 2009
MPhil 2009 QMThe mechanism of transcriptional regulation which allows oral mucosal-specific expression of the human keratin 13 (K13) gene remains unknown.
Aden, Deeqo
core   +4 more sources

Improving the Adsorption Properties of Keratin-Based Goat Hair Toward Reactive Dyes in Dyeing Wastewater by Steam Explosion

Journal of Natural Fibers, 2023
Keratin-based goat hair could be used bioadsorbent due to its large availability, biodegradability and low cost. Unfortunately, most available keratin adsorbents are either low in adsorption capacity or high in preparation cost.
Shijin Wei, Xiuliang Hou, Linyun Liu, Yue Tian, Wei Li, Helan Xu   +5 more
doaj   +1 more source

Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate. [PDF]

Cytometry A, 2020
AbstractCancer cells gain motility through events that accompany modulation of cell shape and include altered expression of keratins. However, the role of keratins in change of cancer cell architecture is not well understood. Therefore, we ablated the expression of keratin 19 (K19) in breast cancer cells of the MDA‐MB‐231 cell line and found that cells
Lam VK, Sharma P, Nguyen T, Nehmetallah G, Raub CB, Chung BM.   +5 more
europepmc   +4 more sources