Results 21 to 30 of about 5,007,575 (281)

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas [PDF]

Gut, 2013
Objective Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying mechanisms driving this phenotype of K19-positive HCC remain elusive. Design
Govaere, Olivier, Komuta, M.Ina, Berkers, Joost, Spee, Bart, Janssen, Carl, de Luca, Francesca, Katoonizadeh, Aezam, Wouters, Jasper, van Kempen, Léon C., Durnez, Anne, Verslype, Chris, De Kock, Joery, Rogiers, Vera, van Grunsven, Leo A., Topal, Baki, Pirenne, Jacques, Vankelecom, Hugo, Nevens, Frederik, van den Oord, Joost, Pinzani, Massimo, Roskams, Tania   +20 more
openaire   +7 more sources

Efficient isolation of keratin from protein-rich waste biomass: a practical approach to minimize environmental impact and valorize waste biomass

Sustainable Environment Research, 2022
Among various protein-containing biomass wastes, waste animal wool, poultry feather, and human hair are considered one of the most important renewable sources of keratin.
Tapan Kumar Maity, Nripat Singh, Pradipkumar Vaghela, Arup Ghosh, Sanju Singh, Pramod B. Shinde, Rosy Alphons Sequeira, Kamalesh Prasad   +7 more
doaj   +1 more source

Keratin 19 Epithelial Patterns in Cirrhotic Stroma Parallel Hepatocarcinogenesis [PDF]

The American Journal of Pathology, 2011
Cirrhotic septa harbor vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively referred to as the ductular reaction (DR). Lack of the DR in the stromal compartment around hepatocellular carcinoma (HCC) has been documented; however, the relationship of epithelial keratin 19 (K19) structures to progression of intralesional ...
Jochen K M, Lennerz, William C, Chapman, Elizabeth M, Brunt   +2 more
openaire   +2 more sources

No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda. [PDF]

PLoS ONE, 2012
It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications for circumcision.
Minh H Dinh, Taha Hirbod, Godfrey Kigozi, Eneniziaogochukwu A Okocha, Gianguido C Cianci, Xiangrong Kong, Jessica L Prodger, Kristina Broliden, Rupert Kaul, David Serwadda, Maria J Wawer, Ronald H Gray, Thomas J Hope   +12 more
doaj   +1 more source

Keratin 19 expression correlates with poor prognosis in breast cancer [PDF]

Molecular Biology Reports, 2014
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression.
Kabir, Nuzhat N., Rönnstrand, Lars, Kazi, Julhash U.   +2 more
openaire   +3 more sources

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma [PDF]

Clinical Cancer Research, 2015
Abstract Purpose: Keratin 19 (K19) is a known marker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determined whether K19 can be used as a new CSC marker and therapeutic target in HCC. Experimental Design:
Takayuki, Kawai, Kentaro, Yasuchika, Takamichi, Ishii, Hokahiro, Katayama, Elena Yukie, Yoshitoshi, Satoshi, Ogiso, Sadahiko, Kita, Katsutaro, Yasuda, Ken, Fukumitsu, Masaki, Mizumoto, Etsuro, Hatano, Shinji, Uemoto   +11 more
openaire   +2 more sources

HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs [PDF]

, 2022
Abstract Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation and cancer metastasis. However, the mechanism of HNRNPK cytoplasmic localization, its cytoplasmic RNA
Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner, Byung Min Chung   +10 more
openaire   +1 more source

An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces

Marine Drugs, 2021
Keratinases present promising biotechnological applications, due to their ability to degrade keratin. Streptomyces appears as one of the main sources of these enzymes, but complete genome sequences of keratinolytic bacteria are still limited.
Ricardo Valencia, Valentina González, Agustina Undabarrena, Leonardo Zamora-Leiva, Juan A. Ugalde, Beatriz Cámara   +5 more
doaj   +1 more source

Two mechanisms regulate keratin K15 expression in keratinocytes:role of PKC/AP-1 and FOXM1 mediated signalling [PDF]

, 2012
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles.
Ahmad Waseem (155362), Amrita Bose, Ahmad Waseem, Leigh, IM, Waseem, Ahmad, Leigh, Irene M., Hutchison, Iain L., Iain L. Hutchison (155346), Hong Wan, Leigh Irene M., Hutchison, IL, Teh, MT, Iain L Hutchison, Muy-Teck Teh, Wan Hong, Teh, M-T, Wan, Hong, Bose, A, Irene M. Leigh (155355), Teh Muy-Teck, Muy-Teck Teh (155335), Amrita Bose (155329), Bose, Amrita, Wan, H, Waseem Ahmad, Irene M Leigh, Waseem, A, Hong Wan (149928), Hutchison Iain L., Teh, Muy-Teck, Bose Amrita   +30 more
core   +1 more source

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis. [PDF]

BMC Cancer, 2016
Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC remain unclear. We attempted to clarify whether K19 directly affects cell survival and invasiveness in association with cellular senescence or ...
Takano M, Shimada K, Fujii T, Morita K, Takeda M, Nakajima Y, Nonomura A, Konishi N, Obayashi C.   +8 more
europepmc   +3 more sources