Results 41 to 50 of about 191,552 (354)

Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]

, 2017
Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S, Arron, Sarah T, Chang, David S, Gupta, Rashmi, Lai, Kevin, Lee, Kristina M, Liao, Wilson, Nititham, Joanne, Rosenblum, Michael, Taravati, Keyon   +9 more
core   +1 more source

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

GJB4 variants linked to skin disease exhibit a trafficking deficiency en route to gap junction formation that can be restored by co-expression of select connexins

Frontiers in Cell and Developmental Biology, 2023
Epidermal keratinocytes are enriched with at least nine connexins that are key regulators of epidermal homeostasis. The role of Cx30.3 in keratinocytes and epidermal health became evident when fourteen autosomal dominant mutations in the Cx30.3-encoding ...
Sergiu A. Lucaciu, Sergiu A. Lucaciu, Rhett Figliuzzi, Ruth Neumann, Samina Nazarali, Luigi Del Sordo, Luigi Del Sordo, Stephanie E. Leighton, Alexandra Hauser, Qing Shao, Danielle Johnston, Donglin Bai, Dale W. Laird, Dale W. Laird   +13 more
doaj   +1 more source

Keratinocyte Growth Factor Promotes Melanosome Transfer to Keratinocytes [PDF]

Journal of Investigative Dermatology, 2005
Melanogenesis and melanosome transfer from the melanocytes to the neighboring keratinocytes are induced by ultraviolet radiation and modulated by autocrine and paracrine factors. Keratinocyte growth factor (KGF/fibroblast growth factor (FGF)7) is a paracrine mediator of human keratinocyte growth and differentiation. We evaluated the influence of KGF on
CARDINALI G, CECCARELLI, SIMONA, KOVACS D, ASPITE N, LOTTI, Lavinia Vittoria, TORRISI, Maria Rosaria, PICARDO M.   +6 more
openaire   +3 more sources

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis

Journal of Inflammation Research, 2022
Kaixuan Ren, Yumin Xia Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, People’s Republic of ChinaCorrespondence: Yumin Xia, Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong
Ren K, Xia Y
doaj  

Nitrogen mustard inhibits keratinocyte proliferation by activating AMPK/autophagy pathway

Di-san junyi daxue xuebao, 2019
Objective To explore the role of AMP-activated protein kinase (AMPK)/ autophagy signaling pathway in nitrogen mustard (NM)-induced cytotoxicity in cultured keratinocytes.
DONG Xunhu, CHEN Mingliang, YE Feng, DAN Guorong, ZOU Zhongmin   +4 more
doaj   +1 more source