Results 121 to 130 of about 639,835 (244)

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Cutaneous Leiomyosarcoma of the Skin: An Updated Review of Epidemiology, Pathogenesis, and Management

International Journal of Dermatology, EarlyView.
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi, Natalie Garcia, Malak Husseinali, Nabeeha Engineer, Ikue Shimizu   +4 more
wiley   +1 more source

Reflectance Confocal Microscopy Integrated With Dermoscopy in a Real‐World Tertiary Referral Cohort: Diagnostic Agreement, Management Outcomes, and Number Needed to Excise in 1057 Lesions

International Journal of Dermatology, EarlyView.
Integrated dermoscopy and reflectance confocal microscopy (RCM) enabled real‐world lesion stratification, demonstrated significant diagnostic concordance, and supported melanoma detection and management in a tertiary referral cohort. ABSTRACT Background Accurate non‐invasive assessment of cutaneous lesions requires integration of diagnostic information
Luca Ambrosio, Claudio Conforti, Giovanni Di Lella, Carmen Cantisani, Francesca Svara, Federico Garbarino, Alessia Paganelli, Camilla Chello, Caterina Longo, Steven Paul Nisticò, Giovanni Pellacani   +10 more
wiley   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomas

Journal of Experimental & Clinical Cancer Research
Abstract Background Monocyte Chemotactic Protein 1-Induced Protein 1 (MCPIP1, also called Regnase-1) is a negative modulator of inflammation with tumor-suppressive properties. Mice with keratinocyte-specific deletion of the Zc3h12a gene, encoding MCPIP1, (Mcpip1eKO mice) are more susceptible to the development of ...
Agata Lichawska-Cieslar, Weronika Szukala, Guillem Ylla, Gabriela Machaj, Faustyna Ploskonka, Iwona Chlebicka, Jacek C. Szepietowski, Jolanta Jura   +7 more
openaire   +5 more sources

A long-term cohort study of acitretin for prevention of keratinocyte carcinoma in solid organ transplant recipients. [PDF]

Australas J Dermatol, 2022
Allnutt KJ, Vogrin S, Li J, Goh MS, Brennand S, Davenport R, Chong AH.   +6 more
europepmc   +1 more source

Implementation of Total Body Photography for Skin Cancer Early Detection: A Systematic Review

International Journal of Dermatology, EarlyView.
This review maps the use of total body photography (TBP) for skin cancer early detection and prevention. It highlights the evolving TBP technologies used, personnel performing imaging, and potential care models employed. Despite this evolution, workflow processes remain broadly consistent, though variably sequenced across settings. ABSTRACT Advances in
Nurul Amanina Binte Hussain, Frances Alice Ansah‐Sasraku, Pablo Fernández‐Peñas, Nicole Gillespie, Peter Hans Soyer, Ingrid Hickman, Monika Janda   +6 more
wiley   +1 more source

Clinical Risk Factors for Cutaneous Squamous Cell Carcinoma in Patients with Actinic Keratosis or Cutaneous Squamous Cell Carcinoma in Situ: A Retrospective Double-cohort Study

Acta Dermato-Venereologica
Actinic keratosis and cutaneous squamous cell carcinoma in situ are precancerous forms of cutaneous squamous cell carcinoma. In this single-centre retrospective study, patients with histopathologically confirmed actinic keratosis (n = 121) or cutaneous ...
Jaakko S. Knuutila, Olli Kaijala, Salla Lehto, Tero Vahlberg, Liisa Nissinen, Veli-Matti Kähäri, Pilvi Riihilä   +6 more
doaj   +1 more source

A Multicenter Prospective Trial of Electronic Skin Surface Brachytherapy for Keratinocyte Carcinoma: Early Cosmesis, Quality of Life, and Adverse Events. [PDF]

Int J Radiat Oncol Biol Phys, 2023
Kuo AM, Lee EH, Rossi AM, Nehal KS, Cordova MA, Steckler AM, Lian M, Cohen G, Zhang Z, Zelefsky MJ, Kasper ME, Barker CA.   +11 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source