Results 161 to 170 of about 1,560,167 (291)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Hair color and risk of keratinocyte carcinoma in US women and men. [PDF]

J Am Acad Dermatol, 2022
Dai J, Li TY, Cho E, Qureshi AA, Li WQ.
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Outcome of elective cemiplimab discontinuation in locally advanced or metastatic cutaneous squamous cell carcinoma patients achieving a complete remission

Frontiers in Oncology
IntroductionCemiplimab treatment of patients with locally advanced or metastatic cutaneous squamous cell carcinoma induced rapid and deep tumor regressions. The majority of our cemiplimab-treated patients achieved a complete remission.
Tina Fung, Wolfram Samlowski, Wolfram Samlowski   +2 more
doaj   +1 more source

Skin Cancer Predisposition Genes, Full‐Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High‐Risk Individuals

International Journal of Dermatology, EarlyView.
ABSTRACT Background There is a lack of knowledge in full‐body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial ...
Jincong Q. Freeman, Yu Matsui, Fangyuan Zhao, Olufunmilayo I. Olopade, Dezheng Huo   +4 more
wiley   +1 more source

Successful treatment of squamous cell carcinoma with intralesional methotrexate

JAAD Case Reports, 2022
L.G. Vega-González, MD, M.I. Morales-Pérez, BA, T. Molina-Pérez, BA, B. Sereno-Gómez, MD   +3 more
doaj   +1 more source

Incidence and geographic differences in keratinocyte carcinoma and Bowen's disease in office‐based dermatological practice between 2013 and 2022: A nationwide Danish registry‐based study

JEADV Clinical Practice
Background Rates of keratinocyte carcinoma (KC) across Europe are impacted by population demographics and geography. Regional differences in KC occurrence exist, but few European studies investigate incidences of specific subtypes in the secondary ...
Johan Sieborg, Merete Haedersdal, Ulrikke Lei, Henrik Sølvsten, Anne Braae Olesen, Gabrielle Randskov Vinding, Anna Lei Lamberg, Alexander Egeberg, Emily Wenande   +8 more
doaj   +1 more source

Assessing the Dermal Epidermal Junction of Hyperkeratotic Actinic Keratoses via Line‐Field Confocal Optical Coherence Tomography

International Journal of Dermatology, EarlyView.
Actinic keratoses (AK) are ultraviolet (UV)‐correlated precursor lesions of invasive cutaneous squamous cell carcinoma (iSCC). AK thickness does not correlate with increased iSCC transformation, but dermal‐epidermal junction (DEJ) protrusion does. The DEJ of hyperkeratotic lesions is harder to study via line‐field confocal optical coherence tomography (
Simone Michelini, Pietro Scribani Rossi, Giuseppe Gemma, Flavia Persechino, Giordano Vespasiani, Claudio Conforti, Francesco Ricci, Carmen Cantisani, Giovanni Pellacani   +8 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

KOH 5% solution versus diclofenac 3% for the treatment of actinic keratosis – Results from a three‐armed RCT

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this RCT, KOH 5% demonstrated superior clinical success to diclofenac 3% and placebo at the end of treatment in patients with mild‐to‐moderate actinic keratosis and comparable long‐term efficacy to diclofenac. Its fast onset of efficacy and favourable tolerability make KOH a valuable treatment option in early‐stage actinic keratosis treatment ...
U. Reinhold, N. Leitz, R. Dominicus, E. L. Szabó, T. Dirschka, G. Popp, T. C. Fischer, N. Adamini, R. Ostendorf, M. Asefi, H. Durani, T. Hölting, U. Amann, F. Kreuziger, T. Assmann, H. Brüning, L. Freitag, K. Hoffmann, R. Gedschold   +18 more
wiley   +1 more source