Results 21 to 30 of about 639,835 (244)
The role of GLI2 in human basal cell carcinoma tumourigenesis [PDF]
, 2010 PhDAbnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC).
Pantazi, Eleni
core +4 more sources
A Model to Predict the Risk of Keratinocyte Carcinomas [PDF]
Journal of Investigative Dermatology, 2016 Basal cell and squamous cell carcinomas of the skin are the commonest cancers in humans, yet no validated tools exist to estimate future risks of developing keratinocyte carcinomas. To develop a prediction tool, we used baseline data from a prospective cohort study (n = 38,726) in Queensland, Australia, and used data linkage to capture all surgically ...
David C. Whiteman +16 more
openaire +6 more sources
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses
Molecular Systems Biology, 2022 Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems.
Llorenç Solé‐Boldo +11 more
doaj +1 more source
Cells, 2023 Cutaneous squamous cell carcinoma (cSCC) is the most common UV-induced keratinocyte-derived cancer, and its progression is characterized by the epithelial–mesenchymal transition (EMT) process.
Enrica Flori +12 more
doaj +1 more source
Public Health Research & Practice, 2022 Objectives: To review the most recent population-based estimates of keratinocyte cancer incidence in Australia, to describe the trends over time and to calculate lifetime risk of developing these skin cancers. Methods: We conducted a literature search
Catherine M Olsen +5 more
doaj +1 more source
Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: A cohort study [PDF]
Journal of the American Academy of Dermatology, 2019 Mary-Margaret Chren +2 more
exaly +2 more sources
The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation [PDF]
, 2010 PhDThe catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity.
Cereser, Biancastella
core +4 more sources
Wnt Signaling Pathways in Keratinocyte Carcinomas [PDF]
Cancers, 2019 The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy.
Christopher M. R. Lang +3 more
openaire +2 more sources
Journal of Skin Cancer, 2022 Context. Keratinocyte carcinomas are the most common malignant condition in Caucasian populations. African albinos have hypomelanized sensitive skin that is quite susceptible to photocarcinogenesis. Of the keratinocyte carcinomas, squamous cell carcinoma
Nnaemeka T. Onyishi, Samuel R. Ohayi
doaj +1 more source