Results 41 to 50 of about 639,835 (244)

A European Consensus on the Consistent Use of the Term “Keratinocyte Cancer”

Acta Dermato-Venereologica
Keratinocyte-derived skin cancers comprise basal cell carcinoma, squamous cell carcinoma, its precursor actinic keratosis, and Bowen’s disease. Historically, this group of neoplasms has been subsumed under the term non-melanoma skin cancer.
Wolfgang G. Philipp-Dormston, Lasse R. Braathen, Colin A. Morton, Merete Haedersdal, Yolanda Gilaberte, Nicole Basset-Seguin, Elena Sotiriou, Stine Regin Wiegell, Piergiacomo Calzavara-Pinton, Thomas Dirschka, Hans Christian Wulf, Günther Hofbauer, Rolf Markus Szeimies   +12 more
doaj   +1 more source

Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

Biomedicines, 2020
Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an aging population and widespread sun exposure.
Luca Fania, Dario Didona, Roberto Morese, Irene Campana, Valeria Coco, Francesca Romana Di Pietro, Francesca Ricci, Sabatino Pallotta, Eleonora Candi, Damiano Abeni, Elena Dellambra   +10 more
doaj   +1 more source

Identification and functional validation of SRC and RAPGEF1 as new direct targets of miR-203, involved in regulation of epidermal homeostasis

Scientific Reports, 2023
The epidermis is mostly composed of keratinocytes and forms a protecting barrier against external aggressions and dehydration. Epidermal homeostasis is maintained by a fine-tuned balance between keratinocyte proliferation and differentiation.
Christelle Golebiewski, Cécile Gastaldi, Diane-Lore Vieu, Bernard Mari, Roger Rezzonico, Françoise Bernerd, Claire Marionnet   +6 more
doaj   +1 more source

Sex Differences in Health-related Quality of Life in Patients with Keratinocyte Carcinomas

Acta Dermato-Venereologica, 2021
The difference between men and women in the impact of keratinocyte carcinomas on quality of life has not been widely studied. This study of 364 patients with keratinocyte carcinoma, measured quality of life using the self-administered 12-item Short Form ...
Francesca Sampogna, Andrea Paradisi, Maria Luisa Iemboli, Luca Fania, Francesco Ricci, Monica Napolitano, Damiano Abeni   +6 more
doaj   +1 more source

Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

Genes and Diseases, 2021
The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes.
Jun Wan, Hongji Dai, Xiaoli Zhang, Sheng Liu, Yuan Lin, Ally-Khan Somani, Jingwu Xie, Jiali Han   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Skin cancer screening: recommendations for data-driven screening guidelines and a review of the US Preventive Services Task Force controversy

Melanoma Management, 2017
Melanoma is usually apparent on the skin and readily detected by trained medical providers using a routine total body skin examination, yet this malignancy is responsible for the majority of skin cancer-related deaths.
Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong   +55 more
doaj   +1 more source

Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study

Acta Dermato-Venereologica, 2020
Cutaneous squamous cell carcinoma (cSCC) has metastatic potential. The aims of this study were to identify the risk factors for metastasis of primary cSCC and for poor prognosis in metastatic cSCC. Retrospective primary tumour cohorts of metastatic cSCCs
Jaakko S. Knuutila, Pilvi Riihilä, Samu Kurki, Liisa Nissinen, Veli-Matti Kähäri   +4 more
doaj   +1 more source

Cutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

Biomedicines, 2021
Cutaneous squamous cell carcinoma (cSCC), a non-melanoma skin cancer, is a keratinocyte carcinoma representing one of the most common cancers with an increasing incidence. cSCC could be in situ (e.g., Bowen’s disease) or an invasive form.
Luca Fania, Dario Didona, Francesca Romana Di Pietro, Sofia Verkhovskaia, Roberto Morese, Giovanni Paolino, Michele Donati, Francesca Ricci, Valeria Coco, Francesco Ricci, Eleonora Candi, Damiano Abeni, Elena Dellambra   +12 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source