Results 51 to 60 of about 639,835 (244)

“Well, to Be Honest, I Don’t Have an Idea of What It Might Be”—A Qualitative Study on Knowledge and Awareness Regarding Nonmelanoma Skin Cancer

Current Oncology, 2023
Nonmelanoma skin cancer (NMSC) is the most common cancer type in Western industrialized countries. However, research into the knowledge and awareness in the general population regarding NMSC is still scarce.
Luisa Leonie Brokmeier, Katharina Diehl, Bianca Annika Spähn, Charlotte Jansen, Tobias Konkel, Wolfgang Uter, Tatiana Görig   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Single-cell transcriptomic landscape of keratinocyte transformation from actinic keratosis to skin carcinoma

iScience
Summary: Cutaneous squamous cell carcinoma (cSCC) develops through a stepwise progression from normal skin (NS) to actinic keratosis (AK) and invasive carcinoma. To delineate the cellular and molecular events underlying this transition, we perform single-
Tao Xu, Zhongzhi Wang, Hao Wu, Yuanjie Zhu, Liangzhe Wang, Siyu Wu, Ti Fu, Xiaolie Wang, Guotai Yao, Shengli Li, Yi Jin, Jianghan Chen   +11 more
doaj   +1 more source

Characteristics and Trends of Cutaneous Squamous Cell Carcinoma in a Patient Cohort in Finland 2006-2015

Acta Dermato-Venereologica, 2019
The incidence of cutaneous squamous cell carcinoma is increasing worldwide. In most epidemiological studies, only the first case of cutaneous squamous cell carcinoma is registered, underestimating the burden of the disease. To determine the frequency and
Niina Korhonen, Leea Ylitalo, Tiina Luukkaala, Julius Itkonen, Henni Häihälä, Juha Jernman, Erna Snellman, Johanna Palve   +7 more
doaj   +1 more source

Squamous cell carcinoma developing in a long-standing case of tuberous xanthoma: An incident unreported hitherto

Indian Dermatology Online Journal, 2015
Cutaneous squamous cell carcinoma, characterized by malignant transformation of normal epidermal keratinocyte is the second most common nonmelanoma skin cancer that has many predisposing factors.
Karan Sancheti, Anupam Das, Indrashis Podder, Swosti Mohanty, Ramesh C Gharami, Prabir K Jash   +5 more
doaj   +1 more source

Expression and functional role of Sox9 in human epidermal keratinocytes. [PDF]

PLoS ONE, 2013
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that Sox9 is predominantly expressed in the basal layer of normal human skin epidermis, and highly expressed in several
Ge Shi, Kyung-Cheol Sohn, Zhengjun Li, Dae-Kyoung Choi, Young Min Park, Jin-Hwa Kim, Yi-Ming Fan, Yong Hee Nam, Sooyeon Kim, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee   +13 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Immunomodulators for Non-Melanoma Skin Cancers: Updated Perspectives

Clinical, Cosmetic and Investigational Dermatology, 2023
Kristen Russomanno,1 Sara Abdel Azim,2 Vishal A Patel3 1Department of Dermatology, Medstar Georgetown University Hospital/Medstar Medical Group, Washington, DC, USA; 2School of Medicine, Georgetown University, Washington, DC, USA; 3Department of ...
Russomanno K, Abdel Azim S, Patel VA
doaj  

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source