Results 71 to 80 of about 639,835 (244)

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Bettina Kempf, Partilla, Miriam, Jens Waschke, Hartlieb, Eva, Waschke, Jens, Kempf, Bettina, Eva Hartlieb (103934), Vigh, Balázs, Miriam Partilla, Miriam Partilla (103942), Balázs Vigh, Bettina Kempf (103938), Eva Hartlieb, Volker Spindler (103952), Balázs Vigh (103947), Jens Waschke (103956), Spindler, Volker, Volker Spindler   +17 more
core   +2 more sources

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

Nature Communications, 2018
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from ...
Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G. Hofmann, Marc Winnefeld, Frank Lyko   +19 more
doaj   +1 more source

AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. [PDF]

, 2012
AHNAK/Desmoyokin is a giant protein which has been recently linked to reorganization of the actin cytoskeleton, cellular migration and invasion. Here, we investigated the role of AHNAK in the pathophysiology of larynx carcinoma-one of the major subtypes ...
Reinhard Zeidler, Zeidler, Reinhard, Brandau, Sven, Sven Br, Bankfalvi, Agnes, Claudia A Dumitru, Dumitru, Claudia A., Lang, Stephan, Stephan Lang, Claudia A. Dumitru, Agnes Bankfalvi, Xiang Gu, Gu, Xiang, Sven Brandau   +13 more
core   +2 more sources

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Health risk assessment of heavy metal accumulation in fruits exposed to geothermal waters: a case study and global implications

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study investigated the potential health risks of heavy metals (HMs) in the fruits and leaves of mulberry and sour cherry trees exposed to water from Sivas geothermal basin (Turkey). RESULTS The target HMs were ranked according to their hazard index as: Cd < Pb < Zn < Cu < Ni < Mn < Cr. The total hazard index for mulberry
E Işıl Arslan Topal, Murat Topal, Erdal Çelik, Erdal Öbek   +3 more
wiley   +1 more source

Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study [PDF]

, 2019
Solid organ transplant recipients have a high risk of keratinocyte carcinoma (non-melanoma skin cancer). Consensus-based transplant guidelines recommend annual dermatological examination but the impact on skin cancer-related outcomes is unclear.
Lianne G. Singer, Chan, AW, An-Wen Chan, Nancy N. Baxter, S. Joseph Kim, Baxter, NN, Kim, SJ, Raed Alhusayen, Alhusayen, R, Singer, LG, Austin, PC, Kinwah Fung, Paula A. Rochon, Fung, K, Rochon, PA, Peter C. Austin   +15 more
core   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. [PDF]

, 2012
PMCID: PMC3312909This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Ahmad Waseem (155362), Emilios Gemenetzidis (176601), Adiam W. Bahta (176614), Nadir, A, Ayesha Nadir, Ahmad Waseem, Deeviyaben Patel (176603), Gemenetzidis Emilios, Iain L. Hutchison (155346), Bahta, AW, Ayesha Nadir (176609), Hutchison, IL, Nadir Ayesha, Teh, MT, Iain L Hutchison, Muy-Teck Teh, Teh, M-T, Rameez Tariq, Gemenetzidis, E, Adiam W Bahta, Teh Muy-Teck, Muy-Teck Teh (155335), Patel, D, Emilios Gemenetzidis, Patel Deeviyaben, Waseem Ahmad, Tariq, R, Waseem, A, Deeviyaben Patel, Rameez Tariq (176604), Tariq Rameez, Hutchison Iain L., Bahta Adiam W.   +32 more
core   +2 more sources

Therapeutic Challenges in Managing Coexisting Hidradenitis Suppurativa and Squamous Cell Carcinoma: A Clinical Case Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder affecting intertriginous areas. Long‐standing HS can undergo malignant transformation into squamous cell carcinoma (SCC), particularly in the perineal and gluteal regions. We report a 54‐year‐old man with severe, treatment‐refractory HS complicated by an aggressive verrucous
Michael Zolotas, Tereza Jakovljevicova, Kamran Ghoreschi, Kerstin Kusch, Marisa Klemp, Robert Sabat, Georgios Kokolakis   +6 more
wiley   +1 more source

The Physician Global Assessment as a Proxy for Photoaging: Validation in an Observational Real‐World Cohort Using SCINEXA as the Reference Standard

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Photoaging is a chronic skin condition caused by cumulative ultraviolet exposure superimposed on intrinsic aging. Although the SCore of INtrinsic and EXtrinsic skin Aging (SCINEXA) is a validated multidimensional instrument for assessing photoaging, the Physician Global Assessment (PGA) is a simpler clinician‐reported measure whose ...
Ewout Baerveldt, Eric van Sprang, Henk‐Jan Ramaker, Robert T. Aeneae Venema, Thomas Rustemeyer, Jorrit Terra, Perry J. J. van Genderen   +6 more
wiley   +1 more source