Results 1 to 10 of about 74,447 (392)

Utility of Keratins as Biomarkers for Human Oral Precancer and Cancer

Life, 2022
Human oral cancer is the single largest group of malignancies in the Indian subcontinent and the sixth largest group of malignancies worldwide. Squamous cell carcinomas (SCC) are the most common epithelial malignancy of the oral cavity, constituting over
Milind Vaidya, Crismita Dmello, Saie Mogre   +2 more
doaj   +2 more sources

The human keratins: biology and pathology

Histochemistry and Cell Biology, 2008
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules.
R. Moll, M. Divo, L. Langbein
exaly   +2 more sources

Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles

BMC Evolutionary Biology, 2014
BackgroundVertebrate skin appendages are constructed of keratins produced by multigene families. Alpha (α) keratins are found in all vertebrates, while beta (β) keratins are found exclusively in reptiles and birds. We have studied the molecular evolution
Matthew J Greenwold, Weier Bao, Erich D Jarvis   +2 more
exaly   +2 more sources

Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus

Frontiers in Immunology, 2018
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly ...
Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y. Radeva, Fanny Buechau, Thomas M. Magin, Volker Spindler, Jens Waschke   +7 more
doaj   +2 more sources

Keratins Are Altered in Intestinal Disease-Related Stress Responses

Cells, 2016
Keratin (K) intermediate filaments can be divided into type I/type II proteins, which form obligate heteropolymers. Epithelial cells express type I-type II keratin pairs, and K7, K8 (type II) and K18, K19 and K20 (type I) are the primary keratins found ...
Terhi O. Helenius, Cecilia A. Antman, Muhammad Nadeem Asghar, Joel H. Nyström, Diana M. Toivola   +4 more
doaj   +2 more sources

Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages [PDF]

Journal of Developmental Biology
Keratins and keratin-associated proteins (KRTAPs) are the main components of mammalian nails and hair. Comparative genomics and gene expression studies have revealed that keratins are conserved in all vertebrates, whereas KRTAPs exist only in mammals ...
Attila Placido Sachslehner, David A. D. Parry, Leopold Eckhart   +2 more
doaj   +2 more sources

Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings [PDF]

Current Issues in Molecular Biology
Keratins 6, 16, and 17 occupy unique positions within the keratin family. These proteins are not commonly found in the healthy, intact epidermis, but their expression increases in response to damage, inflammation, and hereditary skin conditions, as well ...
Daniil D. Romashin, Tatiana V. Tolstova, Alexandra M. Varshaver, Peter M. Kozhin, Alexander L. Rusanov, Natalia G. Luzgina   +5 more
doaj   +2 more sources

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver

Hepatology, 2016
Nam-on Ku, Pavel Strnad, Klaus Schulze-osthoff   +2 more
exaly   +2 more sources

Topographical mapping of α- and β-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives

Proceedings of the National Academy of Sciences of the United States of America, 2015
Ping Wu, Chen Siang Ng, Yung-chih Lai
exaly   +2 more sources

Keratins in health and cancer: more than mere epithelial cell markers

Oncogene, 2011
V. Karantza
exaly   +2 more sources