Results 61 to 70 of about 26,538 (309)

Can keratin scaffolds be used for creating three-dimensional cell cultures? [PDF]

, 2020
Marta Bochyńska-Czyż, Patrycja Redkiewicz, H. Kozłowska, Joanna Matalińska, Marek Konop, Piotr Kossoń   +5 more
openalex   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour

European Journal of Histochemistry, 2013
Using immunohistochemistry, the study demonstrates the distribution of keratins (pan-keratin with CK1-8, 10, 14-16, 19; keratins CK1, 5, 6, 9, 10; hair keratins AE13, AE14) in the epidermis of the Malayan pangolin (Manis javanica).
W. Meyer, M. Liumsiricharoen, A. Suprasert, L.G. Fleischer, M. Hewicker-Trautwein   +4 more
doaj   +1 more source

Epithelium‐Inspired, Ultrahigh‐Toughness, Ultralow‐Hysteresis, and Highly Compressible Polymer Hydrogels as Self‐Powered, Visual, and Underwater Strain Sensors

Advanced Science, EarlyView.
Inspired by epithelial tissue, epithelium‐like structure hydrogels are synthesized. The as‐prepared hydrogels exhibit ultrahigh toughness, ultralow hysteresis, and ultrahigh compressibility, which can be utilized as self‐powered and visual strain sensors.
Yutang Zhou, Honghao Shu, Yuhuan Yao, Bolin Lu, Wenbin Zhong   +4 more
wiley   +1 more source

Keratinases: emerging trends in production and applications as novel multifunctional biocatalysts

Kuwait Journal of Science, 2016
Keratinases are proteolytic enzymes capable of degrading rigid and insoluble keratinous proteins present in skinand appendages. They are produced in the keratinous substrates such as feather, hair, wool, nail, horn and hoof bymicroorganisms.
Isiaka A. Adelere, Agbaje Lateef
doaj  

Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

Advanced Science
Keratins are an integral part of cell structure and function. Here, it is shown that ectopic expression of a truncated isoform of keratin 81 (tKRT81) in breast cancer is upregulated in metastatic lesions compared to primary tumors and patient‐derived ...
Diane S. Kang, Aidan Moriarty, Yiru Jess Wang, Amal Thomas, Jia Hao, Bret A. Unger, Remi Klotz, Shamim Ahmmed, Yonatan Amzaleg, Stuart Martin, Siva Vanapalli, Ke Xu, Andrew Smith, Keyue Shen, Min Yu   +14 more
doaj   +1 more source

Immunohistochemical staining patterns of alpha-keratins in normal tissues from two reptile species: implications for characterization of squamous cell carcinomas

BMC Veterinary Research, 2018
Background Cytokeratins with epitopes in common with those of alpha (acidic and basic) mammalian keratins have been immunohistochemically demonstrated in the epidermis of reptiles. However, there are no reports of immunohistochemical staining patterns of
Jorge Orós, María López-Yánez, Francisco Rodríguez, Pascual Calabuig, Pedro L. Castro   +4 more
doaj   +1 more source

144 Dupilumab restores the equilibrium of keratins and desmosomal components, integral components of the skin barrier cornified envelope [PDF]

, 2023
Elena Goleva, Evgeny Berdyshev, S. Kreimer, Irina Bronova, T. Lyubchenko, S. Bafna, Inoncent Agueusop, Robert Bissonnette, Jeffrey D. Zahn, A. Zhang, Donald Y.M. Leung   +10 more
openalex   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Fibril Structure of Desiccation‐Protective Tardigrade Protein CAHS‐8

Angewandte Chemie, EarlyView.
We present the atomic structure of the fibril formed by an intrinsically disordered protein that has been shown to be responsible for remarkable environmental stress in tardigrades. X‐ray crystallography reveals a unique mechanism of fibril assembly whereby a single helix forms a stable, antiparallel coiled‐coil dimer, which then assembles into a ...
Anas Malki, Jean‐Marie Teulon, Emmi A. Mikkola, Damien Maurin, Jean‐Luc Pellequer, Max H. Nanao, Martin Blackledge   +6 more
wiley   +2 more sources