Livarol in the treatment of chronic vulvovaginal candidiasis
The article presents the results of the study of treatment of women with chronic vulvovaginal candidiasis by vaginal suppositories Livarol, which contain 400 mg of ketoconazole. Treatment was carried out according to two schemes.
Т. С. Дивакова+1 more
doaj +1 more source
Purpose: Various antifungal agents both topical and systemic have been introduced into clinical practice for effectively treating dermatophytic conditions.
VK Bhatia, PC Sharma
semanticscholar +1 more source
Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis-mass spectrometry [PDF]
trans-Ketoconazole was identified and quantified as impurity of cis-ketoconazole, an antifungal compound, by capillary zone electrophoresis–electrospray–mass spectrometry (CZE–ESI–MS).
Castro Puyana, María+4 more
core +2 more sources
Predicting Systemic and Liver Bosentan Exposure Using Physiologically‐Based Pharmacokinetic Modeling
ABSTRACT Bosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black‐box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure. The risk assessment of bosentan‐induced liver injury requires a thorough understanding of the underlying mechanisms, for which there is ...
Miao‐Chan Huang+6 more
wiley +1 more source
Spectrophotometric method for the determination of ketoconazole based on amplification reactions
This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions. Ketoconazole was oxidized with periodate, resulting in formation of KC2+ and iodate ions.
Shaligram S. Rane, P. Padmaja
doaj
Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens. [PDF]
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, including ...
Alsaadi, Abrar I+6 more
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ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal+6 more
wiley +1 more source
7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael+12 more
core +3 more sources
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret+5 more
wiley +1 more source
Comparision between therapeutic efficacy of terbinafine and ketoconazole in Tinea versicolor
Background and Objective: Tinea versicolor is a common fungal infection of the skin caused by the dimorphic lipophilic yeast Pityrosporum orbicular (Malassezia furfur). Lesions begin as multiple small, circular macules of various colors.
Rostami Mogaddam M (MD)+2 more
doaj