Results 41 to 50 of about 26,503 (228)
Clinical Pharmacology &Therapeutics, EarlyView.CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao +8 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Magna Medika, 2023 Trichophyton rubrum is type of fungus that most often causes superficial fungal infections. Development of herbal ingredients as antifungal therapy is carried out to find alternative therapies for fungal infections.
Vika Pangesty +2 more
doaj +1 more source
OPTIMIZATION AND EVALUATION OF TOPICAL KETOCONAZOLE NANOEMULSION
, 2018 Â Objective: The present study is to formulate and optimization of surfactant, cosurfactant, and oil of ketoconazole nanoemulsion.Methods: Ketoconazole was dissolved in surfactant, cosurfactant, and oil until saturated, clear solution extracted with ...
Ramlan Sinaga, Kasmirul +2 more
core +2 more sources
Enhancement of ketoconazole dissolution rate by the liquisolid technique
Acta Pharmaceutica, 2018 The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier ...
Molaei Mir-Ali +5 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
Formulation and Evaluation of Liposomes of Ketoconazole
, 2009 Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. Ketoconazole liposomes were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios.
Hardik Patel, Rakesh Patel, Ashok Baria
core +1 more source
Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility
, 2016 Crystal structures of ketoconazole oxalate salt (1) and three co-crystals with fumaric (2), succinic (3), and adipic (4) acids in 1:1 stoichiometry were determined by single-crystal X-ray diffraction in which 1 forms oxalate dimers involved in ionic ...
Xenia Filip (1904386) +4 more
core +2 more sources
World Rabbit Science, 2017 As considerable inter-species differences exist in xenobiotic metabolism, developing new pharmaceutical therapies for use in different species is fraught with difficulties.
Orsolya Palócz +3 more
doaj +1 more source
Carbohydrate Polymer Technologies and Applications, 2023 Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine.
Viviane Annisa +3 more
doaj +1 more source