Results 51 to 60 of about 26,568 (229)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity

Molecules, 2012
Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages.
Elzbieta Tryniszewska, Pawel Tomasz Sacha, Piotr Wieczorek, Magdalena Wroblewska, Katarzyna Winnicka   +4 more
doaj   +1 more source

Effect of permeation enhancers on the penetration mechanism of transfersomal gel of ketoconazole

Journal of Advanced Pharmaceutical Technology & Research, 2012
The aim of the present research work was to investigate the potential of transfersome formulations for transdermal delivery of Ketoconazole (KTZ). KTZ is a broad-spectrum antifungal agent that is active against a wide variety of fungi and yeasts.
Reshmy Rajan, Deepa T Vasudevan
doaj   +1 more source

EVALUATION OF ANTICANDIDAL EFFECTS OF ESSENTIAL OILS OF COMMERCIAL LAVENDER (Lavandula angustifolia Miller) IN COMBINATION WITH KETOCONAZOLE AGAINTS SOME Candida Berkhout STRAINS

Trakya University Journal of Natural Sciences, 2020
Application of combination studies with essential oils and standard antifungal drugs may reduce adverse effects of synthetic drugs and serve as alternative approach against various pathologies including candidiasis.
Fatih Demirci, Gamze Göger, Burcu Akçal Çomoğlu, Gökalp İşcan   +3 more
doaj   +1 more source

Protein‐Based High‐Performance Liquid Chromatography and Cyclodextrin‐Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles

ELECTROPHORESIS, EarlyView.
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Sarah Moreau, Amy Dillon, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source

Phytochemical Composition and Bioactivity of Elsholtzia strobilifera (Benth.) Benth Essential Oil With Spectral Characterisation of Pinocarvone Using NMR Techniques

Flavour and Fragrance Journal, EarlyView.
Elsholtzia strobilifera (Benth.) EO: in‐depth chemical and biological investigation. ABSTRACT Species of the genus Elsholtzia (Lamiaceae) have been traditionally used in folk medicine and are known for their diverse biological properties. However, the chemical composition and bioactivity of the essential oil from Elsholtzia strobilifera (Benth.) Benth.
Priyanka Bhatt, Pooja Bargali, Gunja Sah, G. C. Shah, Ravendra Kumar, Stefania Garzoli, Maneesha Pathak, Archana N. Sah   +7 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Topical delivery of acyclovir and ketoconazole [PDF]

, 2014
Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of this study was to determine whether
Du Preez, Jan L., Malan, Maides M., Fox, Lizelle T., Du Plessis, Jeanetta, Jacobs, Gerda A., Gerber, Minja   +5 more
core   +2 more sources

???? ???? ????? ??? ????????? ???????? ????????? ?? ???? ??????? ????????? ??????? ???? ?????? ?? ?????? ?????? Ketoconazole

مجلة علوم ذي قار, 2019
This study was performance to investigate the effect of over doses(high dose and long term) of antifungal ketoconazole on body weight, liver weight, Biochemical parameters (ALP, AST and ALT enzymes, as well as total protein and cholesterol ...
حسن عباس
doaj  

Spectrophotometric method for the determination of ketoconazole based on amplification reactions

Journal of Pharmaceutical Analysis, 2012
This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions. Ketoconazole was oxidized with periodate, resulting in formation of KC2+ and iodate ions.
Shaligram S. Rane, P. Padmaja
doaj   +1 more source