Results 21 to 30 of about 28,876 (214)

The Effect of Insulin induced Hypoglycemia on ketoconazole Hepatototxicity in Rabbit [PDF]

The Medical Journal of Basrah University, 2015
Background: Hypoglycemia is one of the most common side effect of insulin treatment, it affect liver and can potentiate ketoconazole toxicity. Objectives: To measure effect of ketoconazole on liver enzymes, hypoglycemic oxidative stress and to evaluate
Nabeel A.J.Ali, Riyad H. Zayer Anaed
doaj   +1 more source

Utilization of alginate with gum acacia/pectin/carrageenan as precipitation inhibitor to improve bioavailability in drug supersaturation: A case study of ketoconazole

Carbohydrate Polymer Technologies and Applications, 2023
Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine.
Viviane Annisa, Teuku Nanda Saifullah Sulaiman, Akhmad Kharis Nugroho, Agung Endro Nugroho   +3 more
doaj   +1 more source

Influence of food on the pharmacokinetics of ketoconazole

, 1984
Eight healthy adults were given single oral doses of ketoconazole (200, 400, 600, and 800 mg) in the fasting state and with a standard breakfast at weekly intervals according to a balanced block design.
Ene, M. D., Williamson, P. J., Daneshmend, T. K., Richardson, M. D., Warnock, D. W., Johnson, E. M., Potten, M. R.   +6 more
core   +11 more sources

Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole

Acta Veterinaria Scandinavica, 2021
Background Ketoconazole, an antifungal agent, adversely affects spermatogenesis in rodents, but knowledge on adverse effects of prolonged administration of ketoconazole on the fertility of male dogs is lacking.
Anna Domosławska, Sławomir Zduńczyk
doaj   +1 more source

High-Performance Liquid Chromatography for Ultra-Simple Determination of Plasma Voriconazole Concentration

Journal of Fungi, 2022
Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu, Yuka Nomura, Yoshito Gando, Yasuhiko Matsumoto, Takashi Sugita, Nobuharu Kosugi, Masayuki Kobayashi   +6 more
doaj   +1 more source

Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome

Frontiers in Endocrinology, 2022
IntroductionTwenty-four-hour urinary free cortisol (24h-UFC) is the most used test for follow-up decision-making in patients with Cushing syndrome (CS) under medical treatment.
Arturo Vega-Beyhart, Arturo Vega-Beyhart, Javier Laguna-Moreno, Daniela Díaz-Catalán, Laura Boswell, Laura Boswell, Mireia Mora, Mireia Mora, Mireia Mora, Mireia Mora, Irene Halperin, Irene Halperin, Irene Halperin, Gregori Casals, Felicia A. Hanzu, Felicia A. Hanzu, Felicia A. Hanzu, Felicia A. Hanzu   +17 more
doaj   +1 more source

Gynecomastia with Ketoconazole [PDF]

Antimicrobial Agents and Chemotherapy, 1981
Three of forty men developed bilateral gynecomastia upon ketoconazole treatment. Symptoms abated despite continued therapy. This appears to be a direct drug effect on breast tissue.
R, DeFelice, D G, Johnson, J N, Galgiani
openaire   +2 more sources

Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans

Microbiology Spectrum, 2021
Candida albicans is a prevalent opportunistic human fungal pathogen for which treatment is limited to only four main classes of antifungal drugs, with the azole and echinocandin classes being used most frequently.
Yi Xu, Hui Lu, Shuo Zhu, Wan-Qian Li, Yuan-ying Jiang, Judith Berman, Feng Yang   +6 more
doaj   +1 more source

Dermatophytic infection and in vitro activities of antifungal drugs against dermatophytes in rural India

Microbiologia Medica, 2021
Background Increase in resistance to conventional antifungals renders the need for antifungal sensitivity testing in Dermatophytes.   The present study aimed at determining the prevalence of dermatophytic infections and their susceptibility ...
Dharmendra Singh, Ankita Sharma, Rajesh Verma, Sweta Kumar, Satender Saraswat   +4 more
doaj   +1 more source

Ketoconazole in the treatment of cryptococcosis of the central nervous system. [PDF]

, 1991
Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it ...
Sander, JW, Silvado, CS, Wittig, EO, Trevisol-Bittencourt, PC, J. W. A. S. Sander, C. S. Silvado, P. C. Trevisol-Bittencourt, E. O. Wittig   +7 more
core   +1 more source