Results 11 to 20 of about 41,377 (223)
Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations. [PDF]
PLoS ONE, 2014 BackgroundThe antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have
Emmelie Björklund +3 more
doaj +8 more sources
Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]
Fundam Clin PharmacolABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc +2 more sources
Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets [PDF]
Journal of the Serbian Chemical Society, 2005 The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25ºC at a constant ionic strength of M(NaCl).
Vojić Mirjana P. +3 more
doaj +3 more sources
Pharmaceuticals, 2023 To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely ...
Hongmei Yu +8 more
doaj +1 more source
Bioengineering & Translational Medicine, 2023 Ionic liquids (ILs) loading ketoconazole (KCZ) have shown better efficacy on rats with tinea pedis than the marketed Daktarin® but clinical studies are still lacking.
Xiying Wu +10 more
doaj +1 more source
The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. [PDF]
, 2015 Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available
Barnard, Andrew H +6 more
core +10 more sources
Pharmaceutics, 2021 Ketoconazole (KET), a synthetic imidazole broad-spectrum antifungal agent, is characterized by its poor aqueous solubility and high molecular weight, which might hamper its corneal permeation.
Tarek A. Ahmed +3 more
doaj +1 more source
Evaluation of ketoconazole as a treatment for Cushing’s disease in a retrospective cohort
Frontiers in Endocrinology, 2022 ObjectiveThe first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission.
Camila Viecceli +10 more
doaj +1 more source
Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017 [PDF]
, 2017 The most common endocrinopathy associated with McCune-Albright Syndrome (MAS) is peripheral precocious puberty (PP) which occurs far more often in girls than in boys.
Eugster, Erica A., Neyman, Anna
core +1 more source
Journal of Pharmaceutical Analysis, 2019 Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol ...
Wenling Yang +8 more
doaj +1 more source