Results 11 to 20 of about 28,876 (214)
Indonesian Journal of Pharmacy, 2021 The use of radiopharmaceuticals for infection detection has gained increasing attention for their application in nuclear medicine. The administration of [99mTc]Tc-ketoconazole may altere pharmacological aspects including interaction data with some ...
Ahmad Kurniawan +4 more
doaj +2 more sources
Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells. [PDF]
PLoS ONE, 2014 Antifungal drug ketoconazole causes severe drug-drug interactions by influencing gene expression and catalytic activity of major drug-metabolizing enzyme cytochrome P450 CYP3A4.
Aneta Novotná +6 more
doaj +2 more sources
Pyrene-linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights. [PDF]
Smart MolA series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Kasundra DV, Patel PN.
europepmc +2 more sources
Global transcriptomic response of Malassezia pachydermatis isolates under ketoconazole-induced stress [PDF]
Frontiers in Veterinary ScienceMalassezia pachydermatis is an opportunistic yeast associated with otitis externa and dermatitis in dogs. Despite reduced susceptibility to azole antifungals has increasingly been reported in M.
Marianna Domán +4 more
doaj +2 more sources
Prevalence of Antimicrobial Use in Small Animal Dermatology Referral Practices in the United States. [PDF]
Vet DermatolABSTRACT Background Antimicrobial resistance is a critical global health concern driven by antimicrobial use. Dermatological conditions are common reasons for antimicrobial prescriptions in small animal practice, yet data on prescribing patterns in veterinary dermatology referral settings are lacking. Hypothesis/Objectives To characterise the frequency,
Santoro D, Bollig ER, Granick JL.
europepmc +2 more sources
مجلة علوم ذي قار, 2019 This study was performance to investigate the effect of over doses(high dose and long term) of antifungal ketoconazole on body weight, liver weight, Biochemical parameters (ALP, AST and ALT enzymes, as well as total protein and cholesterol ...
حسن عباس
doaj +2 more sources
The combination of amoxicillin-clavulanic acid and ketoconazole in the treatment of Madurella mycetomatis eumycetoma and Staphylococcus aureus co-infection. [PDF]
PLoS Neglected Tropical Diseases, 2014 Eumycetoma is a chronic progressive disabling and destructive inflammatory disease which is commonly caused by the fungus Madurella mycetomatis. It is characterized by the formation of multiple discharging sinuses.
Najwa A Mhmoud +3 more
doaj +1 more source
Journal of College of Medical Sciences-Nepal, 2021 Introduction: Many treatments have been attempted in pityriasis versicolor with different reports of success. No direct comparative study between Ketoconazole 400 mg single dose against Ketoconazole 200 mg od for 5 days have been made earlier. The aim of
Harendra Kumar Jha +2 more
doaj +1 more source
Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound? [PDF]
, 2021 Ketoconazole is a strong inhibitor of cytochrome P450 3A4 (CYP3A4) and of P-glycoprotein (P-gp) and is often used as an index inhibitor especially for CYP3A4-mediated drug metabolism. A preliminary physiologically based pharmacokinetic (PBPK) model for
Foerster, Kathrin Isabelle +6 more
core +1 more source