Results 51 to 60 of about 57,314 (316)
British Journal of Clinical Pharmacology, 2015 AIM Apixaban is an orally active inhibitor of coagulation factor Xa and is eliminated by multiple pathways, including renal and non-renal elimination. Non-renal elimination pathways consist of metabolism by cytochrome P450 (CYP) enzymes, primarily CYP3A4,
C. Frost +10 more
semanticscholar +1 more source
Complications of Cushing's syndrome: state of the art [PDF]
, 2016 Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities.
Biller, Beverly M. K +5 more
core +1 more source
ChemBioChem, EarlyView.Coordination of antifungal azoles to rhenium di‐ and tricarbonyl complexes results in compounds with enhanced antimicrobial efficacy—up to 32‐fold minimum inhibitory concentration improvement—against methicillin‐sensitive and methicillin‐resistant Staphylococcus aureus over parent azoles.
Kevin Schindler +12 more
wiley +1 more source
Local sensitivity analysis of a supercritical extraction model
The Canadian Journal of Chemical Engineering, EarlyView.Abstract This study investigates the process of chamomile oil extraction from chamomile flowers. A parameter‐distributed model, consisting of a set of partial differential equations, was used to describe the governing mass transfer phenomena between solid and fluid phases under supercritical conditions using carbon dioxide as the solvent.
Oliwer Sliczniuk, Pekka Oinas
wiley +1 more source
Journal of Fungi, 2022 Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu +6 more
doaj +1 more source
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
ChemMedChem, EarlyView.Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi +7 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2022 BACKGROUND Leishmania parasites cause leishmaniasis that range from self-limiting cutaneous lesions to more serious forms of the disease. The search for potential drug targets focusing on biochemical and metabolic pathways revealed the sterol ...
Débora Cristina de Oliveira Silva Nunes +8 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe +4 more
wiley +1 more source
Biofilm formation in Malassezia pachydermatis strains isolated from dogs decreases susceptibility to ketoconazole and itraconazole [PDF]
, 2014 Malassezia pachydermatis is a commonly isolated yeast in veterinary dermatology that can produce biofilms in vitro and in vivo, lowering its susceptibility to antimicrobial drugs.
Csere, István +3 more
core +1 more source
Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma
Eye &ENT Research, EarlyView.Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen +3 more
wiley +1 more source