Results 191 to 200 of about 25,226 (299)

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

open access: yesEpilepsia, Volume 67, Issue 6, Page 2796-2807, June 2026.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan   +14 more
wiley   +1 more source

Sex-specific systemic and brain metabolic responses to a standardized ketogenic diet in mice. [PDF]

open access: yesLab Anim (NY)
Lorin C   +5 more
europepmc   +1 more source

Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase–amplitude coupling

open access: yesEpilepsia Open, Volume 11, Issue 3, Page 801-813, June 2026.
Abstract Objective Treatment selection for infantile epileptic spasms syndrome (IESS) is complex and multifaceted, and currently no electroencephalogram (EEG) biomarkers can guide this decision by predicting treatment response. We tested the predictive value of phase–amplitude coupling (PAC) as IESS patients are known to have elevated PAC.
Soudeh Mostaghimi   +6 more
wiley   +1 more source

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study

open access: yesEpilepsia Open, Volume 11, Issue 3, Page 1046-1053, June 2026.
Abstract This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2‐q13.1 duplication or deletion syndromes (15q‐DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5
Emanuele Cerulli Irelli   +14 more
wiley   +1 more source

In vivo assessment of the recovery of myocardial pyruvate dehydrogenase activity following a ketogenic diet. [PDF]

open access: yesCardiovasc Res
Chen J   +10 more
europepmc   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

open access: yesEpilepsia Open, Volume 11, Issue 3, Page 847-858, June 2026.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

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