Results 211 to 220 of about 747,960 (296)

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, Volume 67, Issue 9, Page 4536-4550, September 2026.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Ketogenic Diet-Based Therapy for Fatigue in Patients with Multiple Sclerosis. [PDF]

Nutrients
Filippi F, Lorenzut S, Garbo R, Lamon E, Del Negro I, Nilo A, Pez S, Gigli GL, Valente M.   +8 more
europepmc   +1 more source

Intermittent fasting with medium‐chain triglycerides in drug‐resistant epilepsy: A pilot crossover trial

Epilepsia, Volume 67, Issue 9, Page 4618-4630, September 2026.
Abstract Objective Ketogenic dietary therapies can reduce seizure frequency in drug‐resistant epilepsy, but adherence to the classical ketogenic diet is often poor. Intermittent fasting supplemented with medium‐chain triglycerides (MCTs) may offer a more feasible and less restrictive alternative.
Wiebke Hahn, Emily Falk, Ayla Balzter, Tobias Foer, Shanin Maierhofer, Sophia Jaumann, Sascha Strehlau, Leona Möller, Panagiota‐Eleni Tsalouchidou, Katja Menzler, Lars Timmermann, Susanne Knake   +11 more
wiley   +1 more source

A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors. [PDF]

Cell Rep Med
Hajihassani O, Roichman A, Boyer JA, MacArthur M, Cordova R, Loftus A, Boutros CS, Hue JJ, Naji P, Tahhan S, Gallagher P, Beegan W, Shah D, Choi J, Manzoor N, Lei S, Kim C, Rathore M, Shah I, Lebo K, Cheng H, Mudigonda A, Hunter C, Zarei M, Alibeckoff S, Ji K, Graor H, Miyagi M, Vaziri-Gohar A, Brunengraber H, Wang R, Lund PJ, Rothermel LD, Rabinowitz JD, Winter JM.   +34 more
europepmc   +1 more source

Targeting Microglial HDAC3 Enhances Aβ Clearance and Neuroprotection in APP/PS1 Mice: A Ketogenic Diet‐Driven Strategy

Food Frontiers, Volume 7, Issue 5, September 2026.
Ketogenic diet (KD) confers neuroprotection in Alzheimer's disease by inhibiting microglial HDAC3. This simultaneously enhances Aβ clearance via TREM2‐mediated phagocytosis and AMPK–ULK1‐driven autophagy, while suppressing NLRP3 inflammasome activation, ultimately attenuating Aβ/tau pathology and neuronal damage. ABSTRACT Growing evidence suggests that
Mingxiao Zheng, Gabriele Loers, Shengnan Lin, Hans‐Christian Siebert, Qingpeng Wang, Ruiyan Zhang, Xuexing Zheng, Ning Zhang   +7 more
wiley   +1 more source

Investigation of the implementation and utilization of ketogenic diet therapy in China : For the Commission on Standardized Development of Epilepsy Centers and Commission on Ketogenic Diet, China Association Against Epilepsy. [PDF]

Acta Epileptol
Xi W, Lin Y, Tian S, Liao J, Wang Y.
europepmc   +1 more source

Conjugated Linoleic Acid‐Enriched Fermented Dairy Modulates Microbiota and Metabolites to Alleviate MASLD: Insights From Multi‐Omics and Causal Mediation Analysis

Food Frontiers, Volume 7, Issue 5, September 2026.
In a 120‐day randomized trial, CLA‐enriched fermented dairy remodeled the gut microbiota and rewired host metabolic pathways in patients with MASLD. These changes were accompanied by reductions in ALT, total cholesterol, creatinine, and hs‐CRP, supporting a microbiota‐mediated dietary strategy for metabolic and liver health.
Fei Mi, Yanjiao Wang, Jia Xiong, Yiyuan Ma, Hongmei Pan, Jianzhong Yin, Yunmei Chai, Yao Wang, Xin Xu, Ai Zhang, Qingwen Ma, Hui Wang, Dongbai Liu, Shaoxiong Wu   +13 more
wiley   +1 more source

Ketoproof? A systematic classification of pharmaceutical excipients for ketogenic diet therapy. [PDF]

Int J Clin Pharm
El Abdouni S, den Uil MG, Kafa Z, Ribeiro TS, van der Louw EJTM, Ruijgrok EJ, Nijstad AL.   +6 more
europepmc   +1 more source

Reconsidering the impact of saturated fat intake on metabolic health: A critical review of evidence and controversies

Food Biomacromolecules, Volume 3, Issue 3, Page 584-603, September 2026.
Abstract Saturated fats (SFAs) play a complex role in health; therefore, their intake has been a topic of debate in the field of nutrition science. Therefore, this article emphasizes the importance of a balanced diet rather than SFA, considering genetic and metabolic differences, and advocates for the reconsideration of dietary guidelines based on the ...
Akash Kumar, Dipak S. Thorat, Sangeeta Yadav, Pooja Yadav, Jhilam Pramanik, Yogesh V. Ushir, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
wiley   +1 more source