Results 41 to 50 of about 9,766 (126)
Frontiers in Molecular Neuroscience, 2016 The hippocampus is prone to epileptic seizures and is a key brain region and experimental platform for investigating mechanisms associated with the abnormal neuronal excitability that characterizes a seizure.
Masahito Kawamura +2 more
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Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy [PDF]
Frontiers in Molecular Neuroscience, 2016 Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately ~18 months. It is clear that increased survival of brain tumor patients requires the design of new therapeutic modalities ...
Woolf, EC, Syed, N, Scheck, AC
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Complete remission of depression and anxiety using a ketogenic diet: case series
Frontiers in NutritionBackgroundThere is little data that describe the use of ketogenic metabolic therapy to achieve full remission of major depression and generalized anxiety disorder in clinical practice.
Lori Calabrese +2 more
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Frontiers in Neurology, 2019 Epilepsy is a neurological disorder characterized by a long term propensity to produce unprovoked seizures and by the associated comorbidities including neurological, cognitive, psychiatric, and impairment the quality of life.
Fan Chen +3 more
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Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. [PDF]
PLoS ONE, 2009 The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes ...
David N Ruskin +2 more
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Ketogenic Metabolic Therapies for Psychiatric and Neurodevelopmental Disorders
BJPsych OpenAims: Emerging evidence suggests that disruptions in brain energy metabolism – including impaired insulin signalling, altered glucose utilization, and mitochondrial dysfunction – may contribute to psychiatric and neurodevelopmental disorders such as bipolar disorder, schizophrenia, depression, post-traumatic ...
Cristina Fante +3 more
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Cell Death and DiseaseThe ketogenic diet is a controversial approach to cancer therapy. Over 30% of hepatocellular carcinoma (HCC) cases harbor β-catenin activating mutations, among which the S33Y mutation represents a classical hotspot conferring constitutive pathway ...
Huan Li +16 more
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Acta Epileptologica, 2022 Super-refractory status epilepticus (SRSE) is an important neurological emergency associated with high mortality and morbidity and poses a heavy economic burden on patients.
Ya Zeng, Jie Mu, Dong Zhou
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The role of β-hydroxybutyrate testing in ketogenic metabolic therapies
Frontiers in NutritionAccurate assessment of dietary adherence and metabolic outcomes remains a critical challenge in most nutrition studies. Ketogenic metabolic therapies (KMTs) provide a unique advantage by inducing nutritional ketosis and enabling the use of ketone bodies as biomarkers of metabolic state.
Fante, Cristina +5 more
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Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View
International Journal of Molecular SciencesThe disruption of brain energy metabolism, leading to alterations in synaptic signaling, neural circuitry, and neuroplasticity, has been implicated in severe mental illnesses such as schizophrenia, bipolar disorder, and major depressive disorder. The therapeutic potential of ketogenic interventions in these disorders suggests a link between metabolic ...
Smita Sahay +4 more
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