Results 101 to 110 of about 1,090 (155)
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A novel bicyclic ketolide derivative
Bioorganic & Medicinal Chemistry Letters, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Ying, Zhao, Qidong, You, Wenbin, Shen
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Enfermedades infecciosas y microbiologia clinica, 2010
Macrolides and ketolides are two families of antibiotics that share the same mechanism of action. They bind to different bases of the peptidyl transferase center of 23S RNA. The antibacterial spectrum of these drugs virtually overlaps, but dissimilarities in the affinity and number of binding sites results in differences in the intensity of their ...
Nazaret, Cobos-Trigueros +3 more
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Macrolides and ketolides are two families of antibiotics that share the same mechanism of action. They bind to different bases of the peptidyl transferase center of 23S RNA. The antibacterial spectrum of these drugs virtually overlaps, but dissimilarities in the affinity and number of binding sites results in differences in the intensity of their ...
Nazaret, Cobos-Trigueros +3 more
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Novel tethers in ketolide antibiotics
Bioorganic & Medicinal Chemistry Letters, 2007Novel macrolide antibiotics which contain a methylene unit between two nitrogen atoms of carbamate groups or between two nitrogen atoms of one carbamate and one urea group were synthesized using the Curtius rearrangement. Such linkers were shown to be stable under physiological conditions, and the resulting ketolides show potent in vitro and in vivo ...
Takushi, Kaneko +3 more
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Cethromycin: A New Ketolide Antibiotic
Annals of Pharmacotherapy, 2013OBJECTIVE To review the pharmacology, chemistry, microbiology, in vitro susceptibility, mechanism of resistance, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, drug interactions, dosage, and administration of cethromycin, a new ketolide antibiotic.
Mansour, Hanine +3 more
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Telithromycin: The first ketolide antimicrobial
Clinical Therapeutics, 2005Telithromycin is the first of the ketolide antibacterials to receive US Food and Drug Administration (FDA) approval for clinical use. It is approved for the treatment of community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), and acute maxillary sinusitis (AMS) in adults.This article reviews the mechanism of action, in ...
Megan, Nguyen, Eunice P, Chung
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Solithromycin: A novel ketolide antibiotic
American Journal of Health-System Pharmacy, 2017The pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, clinical safety, and current regulatory status of solithromycin are reviewed.Solithromycin is a novel ketolide antibiotic developed for the treatment of community-acquired bacterial pneumonia (CABP).
Buege, Michael J. +2 more
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2011
The macrolides and ketolides represent a class of antibacterial agents with activities against most Gram-positive and selected Gram-negative as well as atypical pathogens including penicillin-resistant microorganisms. Erythromycin, clarithromycin, and azithromycin, the most extensively used macrolides in North America, and the only approved ketolide ...
Ze-Qi Xu +2 more
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The macrolides and ketolides represent a class of antibacterial agents with activities against most Gram-positive and selected Gram-negative as well as atypical pathogens including penicillin-resistant microorganisms. Erythromycin, clarithromycin, and azithromycin, the most extensively used macrolides in North America, and the only approved ketolide ...
Ze-Qi Xu +2 more
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Recent developments in macrolides and ketolides
Current Opinion in Microbiology, 1999Emergence of bacterial resistance to macrolide antibiotics, particularly in Gram-positive bacteria, has been observed. Novel macrolides having C-4" carbamate functional groups and ketolides, the 3-keto derivatives of macrolides, have been found to have activities against macrolide-resistant strains.
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Ketolides: the future of the macrolides?
Current Opinion in Pharmacology, 2002The prevalence of antibiotic resistance in bacterial pathogens associated with community-acquired respiratory tract infections is increasing. Ketolides, semi-synthetic derivatives of erythromycin, overcome the macrolide resistance mechanisms found in Streptococcus pneumoniae and Streptococcus pyogenes, two key pathogens. They also have improved potency
Angela M, Nilius, Zhenkun, Ma
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Ketolides – The Modern Relatives of Macrolides
Clinical Pharmacokinetics, 2009As with other widely used antibacterials, the abundant use of macrolides for management of ambulant infections has promoted emergence of resistance against them. Ketolides are structurally related to macrolides and were developed to overcome macrolide resistance, while sharing pharmacodynamic and pharmacokinetic characteristics.
Zeitlinger, M, Wagner, C C, Heinisch, B
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