Results 51 to 60 of about 1,365 (197)

The energy landscape of the ribosome

Biopolymers, Volume 115, Issue 2, March 2024.
Abstract The ribosome is a prototypical assembly that can be used to establish general principles and techniques for the study of biological molecular machines. Motivated by the fact that the dynamics of every biomolecule is governed by an underlying energy landscape, there has been great interest to understand and quantify ribosome energetics.
Sandra Byju, Asem Hassan, Paul C. Whitford   +2 more
wiley   +1 more source

Intravenous azithromycin plus ceftriaxone followed by oral azithromycin for the treatment of inpatients with community-acquired pneumonia: an open-label, non-comparative multicenter trial

Brazilian Journal of Infectious Diseases
Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome.
Fernando G. Rubio, Clóvis A. Cunha, Fernando L.C. Lundgren, Maria P.J.S. Lima, Paulo J.Z. Teixeira, Julio C.A. Oliveira, Valdir Golin, Waldo L.L.D. Mattos, Herbert K. Mählmann, Edson D. Moreira, Jose R. Jardim, Rodney L.F. Silva, Patricia H.B. Silva   +12 more
doaj   +1 more source

Antimicrobial-Resistant Streptococcus pneumoniae in Canadian Hospitals: Results from the 2007 CANWARD Study

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
BACKGROUND: The Canadian Ward Surveillance Study (CANWARD 2007) tested isolates collected from January to December 2007 from 12 Canadian hospitals to a range of antimicrobial agents.
Aleksandra K Wierzbowski, Franil Tailor, Kim Nichol, James A Karlowsky, Daryl J Hoban, George G Zhanel   +5 more
doaj   +1 more source

Synthesis and Structure–Activity Relationships of α‑Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics

, 2016
An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation.
Daniele Andreotti (1738852), Francesca Cardullo (1738855), Elisa Piga (1738864), Stefano Biondi (1738867), Sergio Lociuro (1738858), Alfredo Paio (1738870), Stjepan Mutak (1738849), Daniele Donati (1533319), Dražen Pavlović (1738861)   +8 more
core   +1 more source

Ketolide agents HMR 3004 and HMR 3647 (telithromycin) inhibit the growth of Plasmodium falciparum in vitro [PDF]

, 2016
Background: Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations.
Mbajiorgu, Felix, Maimela, Eric, Makgatho, Marema   +2 more
core   +1 more source

An Examination of the Differential Sensitivity to Ketolide Antibiotics in ermB Strains of Streptococcus Pyogenes and Streptococcus Pneumoniae

, 2004
Several reports in the literature have described a differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae resistant to erythromycin. Strains of S. pyogenes and S.
Zurawick, Kimberly, Mentens, Nicole, Champney, W. Scott   +2 more
core   +1 more source

Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis

, 2011
Antibiotics targeting the bacterial ribosome typically bind to highly conserved rRNA regions with only minor phylogenetic sequence variations. It is unclear whether these sequence variations affect antibiotic susceptibility or resistance development.
Erik C. Böttger, Björn Oettinghaus, Dimitri Shcherbakov, Mihai Bertea, Shcherbakov, D, Rashid Akbergenov, Subramanian Akshay, Akbergenov, R, Bertea, M, Böttger, E C, Akshay, S, Hobbie, S N, Sven N. Hobbie, Oettinghaus, B, Akshay S, Oettinghaus B, Shcherbakov D, Hobbie SN, Böttger EC, Bertea M, Akbergenov R   +20 more
core   +1 more source

Antibiotic activity against naive and induced Streptococcus pneumoniae biofilms in an in vitro pharmacodynamic model

, 2014
Biofilms play a role in the pathogenicity of pneumococcal infections. A pharmacodynamic in vitro model of biofilm was developed that allows characterization of the activity of antibiotics against viability and biomass by using in parallel capsulated ...
Van Bambeke, Françoise, Vandevelde, Nathalie, Tulkens, Paul M.   +2 more
core   +1 more source

Fluorescence Assay for Studying the Ability of Macrolides To Induce Production of Ribosomal Methylase

, 2002
A screening assay to test the inducing capacity of macrolides by fusing the attenuator of the inducible erm (B) gene from Streptococcus pneumoniae HM28 with the gfpmut1 gene has been
Gervais Clarebout, Roland Leclercq
core   +1 more source

Mechanisms of resistance to telithromycin in Streptococcus pneumoniae [PDF]

, 2005
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolates of resistantStreptococcuspneumoniaehavebeendocumented.Mutations in key telithromycin-binding sites such as domains II and V of the 23S rRNA and ...
Daryl J. Hoban, George G. Zhanel, Tamiko Hisanaga   +2 more
core   +1 more source