Results 131 to 140 of about 167,615 (302)

Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones

Journal of the Brazilian Chemical Society, 1998
Treatment of ethanethiol esters with triethylsilane and palladium on carbon at ambient temperature furnished aldehydes. In addition, a variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents.
Tokuyama Hidetoshi, Yokoshima Satoshi, Yamashita Tohru, Shao-Cheng Lin, Leping Li, Fukuyama Tohru   +5 more
doaj  

Ketone Supplementation for Health and Disease

, 2016
Exogenous ketone supplements rapidly elevate blood ketones in a dose-dependent manner regardless of dietary intake, making them a practical method of inducing therapeutic ketosis for medical use. It is thought that ketone supplementation could be used as
Dominic P. D’Agostino, Angela M. Poff, Shannon L. Kesl   +2 more
core   +1 more source

Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals

Advanced Science, EarlyView.
Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui, Guilhem Poy, Rabab Zehra, Axel Fouques, Vassili Sergan, Ivan Dozov, Claire Meyer, Patrick Davidson   +7 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Thiofunctionalization of Silyl Enol Ether: An Efficient Approach for the Synthesis of β-Keto Sulfides

Molecules
β-Keto sulfides are a class of compounds containing both carbonyl (C=O) and thioether (C–S–C) functionalities, exhibiting significant potential in the field of medicinal chemistry.
Xinyao Zhao, Hexia Ye, Yajie Fu, Haibo Liu, Xiaojing Bi   +4 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Ketone-Catalyzed Decomposition of Peroxynitrite via Dioxirane Intermediates

, 2016
Ketones are found to be catalysts for the decomposition of peroxynitrite. Kinetics, product studies, and B3LYP transition-state calculations together provide consistent evidence for a mechanism involving the formation of dioxirane ...
Michael D. Bartberger (1261599), Xue-Chao Wang (2998758), Yeung-Chiu Tang (3004464), K. N. Houk (1247004), Dan Yang (65758), Jian Chen (15340), Leif Olson (3006684)   +6 more
core   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Y(OTf)₃-Salazin-Catalyzed Asymmetric Aldol Condensation

Molecules
The chiral aziridine-containing vicinal iminophenol tridentate ligands (named salazins) are a class of readily prepared chiral ligands from enantiopure aziridines and salicylaldehydes.
Chengzhuo Wang, Ning Chen, Zhanhui Yang, Jiaxi Xu   +3 more
doaj   +1 more source

Voltage‐Reconfigurable Magneto‐Ionic Nanolayers in Dot Arrays for Probabilistic, Materials‐Engineered Security Primitives

Advanced Science, EarlyView.
A magneto‐ionic security‐by‐materials‐design strategy exploits voltage‐driven N3– migration in selectively contacted FeCoN dots, creating reconfigurable sub‐15 nm ferromagnetic sublayers with deterministic and/or probabilistic (single‐domain↔vortex) states, voltage‐tunable probabilities and fully stochastic orientation/chirality.
Irena Spasojevic, Federica Celegato, Alessandro Magni, Paola Tiberto, Jordi Sort   +4 more
wiley   +1 more source